Gentamicin Antibody (1.BB.894): sc-57740

Gentamicin Antibody (1.BB.894) is a mouse monoclonal IgG2a antibody that detects Gentamicin protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-Gentamicin antibody (1.BB.894) is available as a non-conjugated isotype antibody. Gentamicin, an aminoglycoside antibiotic derived from Micromonospora purpurea and related species, plays a crucial role in treating various bacterial infections, particularly those caused by Gram-negative bacteria. Gentamicin′s mechanism of action involves binding to the bacterial 30S ribosomal subunit, which inhibits the translocation of peptidyl-tRNA from the A-site to the P-site, leading to misreading of the genetic code. This disruption prevents the synthesis of essential proteins necessary for bacterial growth and survival. Gentamicin′s unique property of being heat-stable allows retention of efficacy even after autoclaving, making Gentamicin particularly valuable in the preparation of certain microbiological growth media. With a molecular weight of 477.596 g/mol, Gentamicin must be administered intravenously, intramuscularly, or topically, as oral intake results in inactivation during absorption in the small intestine.

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Gentamicin Antibody (1.BB.894) References:

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2. Electrochemical oxidation of drug residues in water by the example of tetracycline, gentamicine and aspirin.  |  Weichgrebe, D., et al. 2004. Water Sci Technol. 49: 201-6. PMID: 15077972
3. Gentamicin nephrotoxicity--a comparison of in vitro findings with in vivo experiments in equines.  |  van der Harst, MR., et al. 2005. Vet Res Commun. 29: 247-61. PMID: 15736857
4. Oral solid gentamicin preparation using emulsifier and adsorbent.  |  Ito, Y., et al. 2005. J Control Release. 105: 23-31. PMID: 15908031
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6. Drug absorption from the small intestine in immediate postoperative patients.  |  Kennedy, JM. and van Rij, AM. 2006. Br J Anaesth. 97: 171-80. PMID: 16731573
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8. 99mTc-gentamicin: chemical and biological evaluation.  |  Ozker, K. and Urgancioğlu, I. 1981. Eur J Nucl Med. 6: 173-6. PMID: 7215382
9. Gentamicin uptake by cochlear hair cells precedes hearing impairment during chronic treatment.  |  Hiel, H., et al. 1993. Audiology. 32: 78-87. PMID: 8447764