Gemcitabine Monophosphate Formate Salt CAS: 116371-67-6
MF: C10H14F2N3O9P
MW: 389.20
An antineoplastic agent.

Gemcitabine Monophosphate Formate Salt (CAS 116371-67-6)

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Alternate Names: 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Formate
Application: Gemcitabine Monophosphate Formate Salt is an antineoplastic agent
CAS Number: 116371-67-6
Purity: ≥95%
Molecular Weight: 389.20
Molecular Formula: C10H14F2N3O9P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Gemcitabine Monophosphate Formate Salt is a deoxycytidine analog which acts as an anticancer agent. It is believed that Gemcitabine Monophosphate Formate Salt functions by incorporating itself in the DNA of the cell and blocking DNA polymerases. Gemcitabine Monophosphate Formate Salt also inhibits ribonucleotide reductase via irreversibly binding to the enzymes active site. This inhibition stops the production of deoxyribonucleotides and so DNA replication ceases.


References

1. Gandhi, V., et al. 1996. Cancer Res. 56: 4453-4459. PMID: 8813140
2. Kotchetkov, R., et al. 2000. Anticancer Res. 20: 2915-2922. PMID: 11062701

Physical State :
Solid
Solubility :
Soluble in Methanol
Storage :
Store at -20° C
Melting Point :
>250° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
NC1=NC(=O)N(C=C1)[[email protected]@H]1O[[email protected]](COP(O)(O)=O)[[email protected]](O)C1(F)F

Download SDS (MSDS)

Certificate of Analysis

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Can this product be stored in solution?

Asked by: hawkeye11
For this chemical, Gemcitabine Monophosphate Formate Salt (CAS 116371-67-6), it is recommended to use the solution the same day that the solution is made. If it must be stored, store at -20ºC. We do not have information on the stability.
Answered by: Chemical Support 1
Date published: 2017-03-31
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