GemcitabineA nucleoside analog with anti-cancer properties

Gemcitabine (CAS 103882-84-4)

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Synonym: 2',2'-Difluoro-2'-deoxycytidine
Application: A nucleoside analog with anti-cancer properties
CAS Number: 103882-84-4
Molecular Weight: 263.20
Molecular Formula: C9H11F2N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Gemcitabine is a nucleoside analog with anti-cancer properties. It works by replacing one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the faulty nucleoside, resulting in apoptosis.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60750
MDL Number :
MFCD00869720
SMILES :
C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F

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Gemcitabine  Product Citations

See how others have used Gemcitabine. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 31374291  Li, X.|He, S.|Tian, Y.|Weiss, RM.|Martin, DT.| et al. 2019. Cell. Signal. 63: 109381.

PMID: # 29650681  Santinon, G. et al. 2018. EMBO J. 37:

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 22233582  Wennier, ST. et al. 2012. Mol. Ther. 20: 759-68.

Citations 1 to 4 of 4 total

Dear Sir/Madam I could not find certificate of analysis for Gemcitabine (CAS 103882-84-4). I just want to know the purity of this product and whether it is the hydrochloride salt or not. Truly yours, Milad

Asked by: Milad
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26
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