GDC-0980 selectively inhibits the activities against class I PI3K and mTOR kinase with a Ki of 17 nM for mTOR (FRAP) and IC50 of 5 nM, 27 nM, 7 nM, and 14 nM for PI3Kα, β, δ, and γ, respectively. GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells.
Soluble in DMSO (20 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Store at -20° C
~718.6° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
n20D 1.68 (Predicted)
PI 3-kinase p110α: IC50 = 4.8 nM (human); PI 3-kinase p110 δ: IC50 = 6.7 nM (human); PI 3-kinase p110γ: IC50 = 14 nM (human); PI 3-kinase p110β: IC50 = 27 nM (human); Syk: IC50 = 134 nM (human)
mTOR: Ki= 17 nM (human)
pKa: 13.9 (Predicted), pKb: 5.03 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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