Gardiquimod CAS: 1020412-43-4
MF: C17H23N5O
MW: 313.40
A TRL7 activator.

Gardiquimod (CAS 1020412-43-4)

Gardiquimod | CAS 1020412-43-4 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-(4-Amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
Application: Gardiquimod is a TRL7 activator
CAS Number: 1020412-43-4
Purity: ≥98%
Molecular Weight: 313.40
Molecular Formula: C17H23N5O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Gardiquimod is a selective ligand for human or mouse toll-like receptor 7 (TLR7), which leads to the activation of NF-κB in HEK 293 cells expressing TLR7. At high concentrations (3 μg/ml), it slightly activates TLR8. Gardiquimod has more activity than imiquimod (sc-200385).

Physical State :
Solid
Solubility :
Soluble in DMSO (>40 mg/ml), dioxane (7 mg/ml), methanol (>40 mg/ml), and acetonitrile (2 mg/ml).
Storage :
Store at -20° C
Boiling Point :
561.97° C at 760 mmHg (Predicted)
Density :
1.29 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
TLR7: IC50 = 2.07 µM (human)
pK Values :
pKb: 8.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
MDL Number :
MFCD11041176
SMILES :
CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N

Download SDS (MSDS)

Certificate of Analysis

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Gardiquimod (CAS 1020412-43-4)  Product Citations

See how others have used Gardiquimod (CAS 1020412-43-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27588480  Oncotarget. 63856-63869.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Zou et al Zou et al. (PubMed ID 26238718) used the TLR7 agonist, gardiquimod, to inhibit pancreatic cancer cell proliferation and to induce apoptosis via changes in gene expression. -SCBT Publication Review
Date published: 2015-05-11
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