GANT61 is a cell-permeable hexahydropyrimidine compound, shown to be an inhibitor of GLI-mediated gene transactivation. GLI-mediated transcription is the final step in the Hedgehog (Hh) signaling pathway, therefore GANT61 halts hedgehog pathway effects. Sonic hedgehog, a homolog of Hedgehog is essential for proper embryonic development and the interference of GANT61 with its production could lead to potential developmental issues. Additionally, this compound was found to successfully inhibit proliferation of tumor cells in vitro in a GLI-dependent manner. GANT61 is an inhibitor of GLI-1 and GLI-2.
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2. Guan, Cheng-Chao., et al., 2009. Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cells. Bone. 45(6): 1146-52. PMID: 19683085
3. Stanton, Benjamin Z., et al., 2010. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Molecular bioSystems. 6(1): 44-54. PMID: 20024066
See how others have used GANT61. Click on the entry to view the PubMed entry .
PMID: # 23757299 Zhu, G. et al. 2013. Oncol. Rep. 30: 904-10.
PMID: # 31758086 Lab. Invest.
PMID: # 30790292 J. Cell. Physiol. 234: 17392-17404.
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