Ganglioside GM1 sodium saltA specific receptor for cholera toxin
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Ganglioside GM1 sodium salt (CAS 37758-47-7)

Ganglioside GM1 sodium salt | CAS 37758-47-7 is rated 5.0 out of 5 by 1.
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Synonym: GANGLIOSIDE GM1
Application: A specific receptor for cholera toxin
CAS Number: 37758-47-7
Purity: >98%
Molecular Weight: 1568.82
Molecular Formula: C73H130N3O31•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ganglioside GM1 sodium salt is a specific and only receptor for cholera toxin which facilitates the toxin's transmembrane movement. Cells which lack Ganglioside GM1 can be toxin-resistant, further proving the role of this receptor in the cholera toxicity mechanism. Experiments have shown Ganglioside GM1 and bis(monoacylglycerol)phosphate (BMP) mixtures to spontaneously form small spherical vesicles of homogenous size in an energy independent manner. In addition, this receptor has been found to significantly decrease hydrogen peroxide-induced reactive oxygen species accumulation in PC-12 (sc-2250) cells. It has been shown that the reduction in reactive oxygen species is due to activation of protein kinase perceiving signal from this enzyme and tyrosine kinase Trk-receptors. We supply the Ganglioside GM1 sodium salt form.


References

1. Fishman, P.H. 1982. J. Membr. Biol. 69: 85-97. PMID: 6752418
2. Vlasova, I.u.A., et al. 2009. Zh. Evol. Biokhim. Fiziol. 45: 465-471. PMID: 19886192
3. Chebukati, J.N., et al. 2010. Biochem. Biophys. Res. Commun. 394: 509-514. PMID: 20206128
4. Hac-Wydro, K., et al., P. 2010. Colloids Surf B Biointerfaces. 81: 385-388. PMID: 20692132

Appearance :
Lyophilized
Physical State :
Solid
Solubility :
Soluble in water (partly), and chloroform/ methanol (1:1).
Storage :
Store at -20° C
Refractive Index :
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Merck Index :
14: 4364
MDL Number :
MFCD00466936
SMILES :
CCCCCCCCCCCCC/C=C/[C@H]([C@@H](NC(=O)CCCCCCCCCCCCCCCCC)CO[C@@H]1OC(CO)[C@H](C(C1O)O)O[C@@H]1OC(CO)[C@@H]([C@@H](C1O)O[C@@]1(C[C@@H](O)[C@H](C(O1)[C@H]([C@@H](CO)O)O)NC(=O)C)C(=O)[O-])O[C@H]1OC(CO)[C@@H](C(C1NC(=O)C)O[C@@H]1OC(CO)[C@@H](C(C1O)O)O)O)O.[Na+]

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Certificate of Analysis

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Ganglioside GM1 sodium salt  Product Citations

See how others have used Ganglioside GM1 sodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26751695  Li, L. et al. 2016. PloS one. 11: e0144219.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Sasaki Sasaki, N. et al. (PubMed 26338710) reported that Ganglioside GM1 contributes to the state of insulin resistance in senescent human arterial endothelial cells. -SCBT Publication Review
Date published: 2015-02-21
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