Ganglioside GM1, AsialoA sialic acid-containing glycolipid known to modulate cell signal transduction

Ganglioside GM1, Asialo (CAS 71012-19-6)

Ganglioside GM1, Asialo | CAS 71012-19-6 is rated 5.0 out of 5 by 1.
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Synonym: ASIALOGANGLIOSIDE-GM1
Application: A sialic acid-containing glycolipid known to modulate cell signal transduction
CAS Number: 71012-19-6
Molecular Weight: 1255.56
Molecular Formula: C62H114N2O23
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ganglioside GM1, Asialo is a product that is a highly purified sialic acid-containing glycolipid; a component of the cell plasma membrane known to modulate cell signal transduction. Ganglioside GM1, Asialo can be a useful marker of cell types and antigens. It has been reported to spontaneously form small homogeneous vesicles without any protein templating. In response to ganglioside GM1, it has been reported that T cells from Guillain-Barrε syndrome patients produce interferon-gamma, a cytokine that is critical for the formation of adaptive immunity against bacterial or viral infections.


References

1. Schengrund, C.L., et al. 1989. J. Biol. Chem. 264: 13233-13237. PMID: 2666416
2. Schroder, K., et al. 2004. J. Leukoc. Biol. 75: 163-189. PMID: 14525967
3. Chebukati, J.N., et al. 2010. Biochem. Biophys. Res. Commun. 394: 509-514. PMID: 20206128
4. McCombe, P.A., et al. 2010. J Clin Neurosci. 17: 537-538. PMID: 20093028

Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Semisynthetic from GM1
Sequence :
GgOse4Cer; β-Gal-(1→3)-β-GalNAc-(1→4)-β-Gal-(1→4)-β-Glc-(1→1')-Cer
Solubility :
Soluble in chloroform:MeOH (2:1).
Storage :
Store at -20° C
Boiling Point :
1302.02° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6450363
MDL Number :
MFCD00131128
SMILES :
CCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)O)O)NC(=O)C)O)O)O)O)C(C=CCCCCCCCCCCCCC)O

Download SDS (MSDS)

Certificate of Analysis

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hello is this asialo or sialic acid-containing ganglioside?

Asked by: pank007
Thank you for your question. Ganglioside GM1, Asialo: sc-202625 has an alternate name that is Asialoganglioside-GM1. If this does not answer your question, please contact our Technical Service Department for more information. Please call us toll-free at (800) 457-3801 option 2, e-mail <scbt@scbt.com>, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-10-13
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Rated 5 out of 5 by from McCombe McCombe, PA. et al. (PubMed 20093028) reported that T cells from subjects with Guillain-Barr syndrome produce interferon-gamma in response to stimulation with Ganglioside GM1, Asialo. -SCBT Publication Review
Date published: 2015-04-28
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