Ganglioside GD3, Disialo, Disodium salt, Bovine ButtermilkA compound reported to disrupt mitochondrial transmembrane potential

Ganglioside GD3, Disialo, Disodium salt, Bovine Buttermilk (CAS 62010-37-1)

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Synonym: Neu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2Na
Application: A compound reported to disrupt mitochondrial transmembrane potential
CAS Number: 62010-37-1
Molecular Weight: 1516.8
Molecular Formula: C70H123N3O292Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ganglioside GD3, Disialo, Diammonium Salt has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. Reported to disrupt mitochodrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. A protein kinase C inhibitor.


References

DeMaria, R., et al. 1997. Science 277, 1652.

Physical State :
Solid
Solubility :
Soluble in Chloroform:Methanol (2:1), and water (1 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760459
MDL Number :
MFCD02098585
SMILES :
CCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)OC3 (CC(C(C(O3)C(C(CO)OC4(CC(C(C(O4)C(C(CO)O)O)NC(=O)C)O)C(=O)[O-])O)NC(=O) C)O)C(=O)[O-])O)O)O)C(C=CCCCCCCCCCCCCC)O

Download SDS (MSDS)

Certificate of Analysis

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