Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Gangliosides are membrane-bound, sialic acid-containing glycosphingolipids that play a significant role in determining the nature of tetraspanin interactions. Ganglioside GD3 is produced by the transfer of sialic acid from CMP-sialic acid to GM3. This reaction is catalyzed by the type II membrane protein GD3 Synthase. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. It is found in most normal tissues, and its expression increases under pathological conditions and during development and aging processes. In malignant melanoma cells, Ganglioside GD3 is involved in the upregulation of tyrosine phosphorylation for p130 Cas and paxillin. Ganglioside GD3 also mediates apoptosis, functioning as a regulatory molecule and contributing to mitochondrial damage. The level of Ganglioside GD3 present in a cell plays a significant role in determining cell fate.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can Ganglioside GD3 (MB3.6): sc-33685 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?
Asked by: Trav11
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Ganglioside GD3 (MB3.6): sc-33685 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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