gamma-Secretase Inhibitor XVIA γ-secretase inhibitor that selectively blocks Aβ dimer and trimer formation

γ-Secretase Inhibitor XVI (CAS 208255-51-0)

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Synonym: N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine Methyl Ester
Application: A γ-secretase inhibitor that selectively blocks Aβ dimer and trimer formation
CAS Number: 208255-51-0
Molecular Weight: 390.4
Molecular Formula: C20H20F2N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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γ-Secretase Inhibitor XVI A cell-permeable γ-secretase inhibitor with anti-aggregation properties. The compound prevents early Aβ oligomerization by selectively blocking the Aβ dimer and Aβ trimer formation.


References

1. Walsh, Dominic M., et al., 2002. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416(6880): 535-9. PMID: 11932745

Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10452973
SMILES :
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC)NC(=O)CC2=CC(=CC(=C2)F)F

Download SDS (MSDS)

Certificate of Analysis

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