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γ-Secretase Inhibitor XVI A cell-permeable γ-secretase inhibitor with anti-aggregation properties. The compound prevents early Aβ oligomerization by selectively blocking the Aβ dimer and Aβ trimer formation.
1. Walsh, Dominic M., et al., 2002. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416(6880): 535-9. PMID: 11932745
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