gamma-Secretase Inhibitor IA γ-secretase inhibitor

γ-Secretase Inhibitor I (CAS 133407-83-7)

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Synonym: Z-LLNle-CHO
Application: A γ-secretase inhibitor
CAS Number: 133407-83-7
Purity: ≥90%
Molecular Weight: 475.6
Molecular Formula: C26H41N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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γ-Secretase Inhibitor is an inhibitor of γ-secretase, a protease that cleaves the amyloid precursor protein (APP). The inhibition of the γ-secretase enzyme is being researched for possible preventative properties towards Alzheimer's disease.


References

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810. Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

Physical State :
Solid
Sequence :
Z-Leu-Leu-Nle-CHO (Nle = Norleucine)
Solubility :
Soluble in 50% acetic acid, and DMSO (10 mg/ml).
Storage :
Store at -20° C
Boiling Point :
686.55° C at 760 mmHg (Predicted)
Density :
1.07 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760646
SMILES :
CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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