gamma-Linolenic Acid (18:3, n-6)An antitumor agent

γ-Linolenic Acid (18:3, n-6) (CAS 506-26-3)

γ-Linolenic Acid (18:3, n-6) | CAS 506-26-3 is rated 5.0 out of 5 by 1.
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Synonym: gamolenic acid
Application: An antitumor agent
CAS Number: 506-26-3
Purity: 99%
Molecular Weight: 278.43
Molecular Formula: C18H30O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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γ-Linolenic acid, is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown γ-Linolenic Acid to have induced reactive oxygen species generation including lipid peroxidation, cell growth inhibition, and heme oxygenase-1 production for antioxidant protection against oxidative stress. Further experiments have noted that γ-Linolenic acid inhibits inflammatory responses through inactivation of NFκB and activator protein-1 by suppressed oxidative stress.


References

1. Fujiwara, F., et al. 1986. Prostaglandins Leukot Med. 23: 311-320. PMID: 3020590
2. van der Merwe, C.F., et al. 1990. Prostaglandins Leukot. Essent. Fatty Acids. 40: 199-202. PMID: 2169638
3. Ranieri, M., et al. 2009. Int J Immunopathol Pharmacol. 22: 45-50. PMID: 19887043
4. Chang, C.S., et al. 2010. Inflammation. 33: 46-57. PMID: 19842026
5. Itoh, S., et al. 2010. J Clin Biochem Nutr. 47: 81-90. PMID: 20664735

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol, DMSO, and DMF(PBS pH7.2). Insoluble in water.
Storage :
Store at -20° C
Refractive Index :
n20D 1.48
Ki Data :
[3H]-LTB4 binding to porcine neutrophil membranes: Ki= 1 µM
pK Values :
pKa: 4.72
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5280933
Merck Index :
14: 5507
MDL Number :
MFCD00065718
Beilstein Registry :
1712253
SMILES :
CCCCC/C=C\\C/C=C\\C/C=C\\CCCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Chang Chang, CS. et al. (PubMed 19842026) reported that -Linolenic Acid (18:3, n-6) inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. -SCBT Publication Review
Date published: 2015-01-05
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