GaleteroneCAS: 851983-85-2
MF: C26H32N2O
MW: 388.55
An antagonist to LNCaP AR.

Galeterone (CAS 851983-85-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 114ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: TOK-001
Application: An antagonist to LNCaP AR
CAS Number: 851983-85-2
Purity: ≥98%
Molecular Weight: 388.55
Molecular Formula: C26H32N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Galeterone is effective at preventing binding of [3H]-R1881 to the mutant LNCaP AR (T877A) and to T575A mutant AR in PC3 cells with IC50 values of 845 nM and 454 nM, respectively. The effects on AR significantly reduce cellular phospho-4EBP1 levels. Galeterone potently inhibits the proliferation of LNCaP and LAPC4 cells in the with IC50 values of 2.6 μM and 4 μM, respectively. Galeterone induces the endoplasmic reticulum s.tress response resulting in down-regulation of cyclin D1 protein expression and cyclin E2 mRNA. in vitro.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11188409
SMILES :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Galeterone  Product Citations

See how others have used Galeterone. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27174722  Bogner, J. et al. 2017. J. Steroid Biochem. Mol. Biol. 166: 45-53.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 173ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.