Galanthamine HydrobromideA competitive and reversible acetylcholinesterase inhibitor

Galanthamine Hydrobromide (CAS 1953-04-4)

Galanthamine Hydrobromide | CAS 1953-04-4 is rated 5.0 out of 5 by 1.
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Synonym: Nivalin;Razadyne
Application: A competitive and reversible acetylcholinesterase inhibitor
CAS Number: 1953-04-4
Purity: ≥98%
Molecular Weight: 368.3
Molecular Formula: C17H21NO3•HBr
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Galanthamine Hydrobromide is a competitive and reversible AChE (acetylcholinesterase) inhibitor, which displays allosteric potentiating effects at nicotinic receptors. In addition, Galanthamine Hydrobromide affects cholinergic transmission and the release of neurotransmitters such as monoamines, glutamate, and γ-aminobutyric acid (GABA). As a result of its inhibitory effects on acetylcholinesterase, Galanthamine Hydrobromide increases the concentration of acetylcholine in the brain.


References

1. Yonkov, D.I. and Georgiev, V.P. 1990. Neuropeptides. 16: 157-162. PMID: 1964494
2. Thomsen, T., et al. 1991. Eur J Clin Chem Clin Biochem. 29: 487-492. PMID: 1954303
3. Dal-Bianco, P., et al. 1991. J. Neural Transm. Suppl. 33 : 59-63. PMID: 1753253
4. Chopin, P. and Briley, M. 1992. Psychopharmacology. 106: 26-30. PMID: 1738791
5. Radicheva, N., et al. 1996. Methods Find Exp Clin Pharmacol. 18: 301-308. PMID: 8817464
6. Ago, Y., et al. 2011. J. Pharmacol. Sci. 116: 6-17. PMID: 21498956

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in ethanol (4 mg/ml), DMSO (10 mg/ml), water (1:0.5), and chloroform (1:5).
Storage :
Store at -20° C
Melting Point :
256° C (lit.)
IC50 :
Acetylcholinesterase: IC50 = 410 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DF8075000
PubChem CID :
121587
Merck Index :
14: 4340
MDL Number :
MFCD00067672
EC Number :
217-780-5
SMILES :
CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O.Br

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Certificate of Analysis

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Galanthamine Hydrobromide  Product Citations

See how others have used Galanthamine Hydrobromide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27655295  Faria, M. et al. 2017. Arch. Toxicol. 91: 1891-1901.

Citations 1 to 1 of 1 total

What is the shipping temperature of this product?

Asked by: hawkeye11
Thank you for your question. The compound, sc-200179, can be shipped at room temperature as the melting point range is from 281-283ºC. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-31
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Rated 5 out of 5 by from Galanthamine Hydrobromide was reported as Galanthamine Hydrobromide was reported as a acetylcholinesterase inhibitor, usually used in alzheimer research. -SCBT Publication Review
Date published: 2015-06-13
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