Fusicoccin CAS: 20108-30-9
MF: C36H56O12
MW: 680.82

Fusicoccin (CAS 20108-30-9)

Fusicoccin | CAS 20108-30-9 is rated 5.0 out of 5 by 1.
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Application: Fusicoccin is a toxin that complexes with 14-3-3 , causes cell hyperpolarization and is and activator of H(+)-ATPase
CAS Number: 20108-30-9
Purity: ≥90%
Molecular Weight: 680.82
Molecular Formula: C36H56O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fusicoccin, a toxin originally extracted from Fusicoccum amygdali Del., is shown to be an activator of H(+)-ATPase. Mechanistic studies suggest that Fusicoccin forms a complex with the 14-3-3 proteins of the ATPase and activates H+ pumping across the plasma membrane. Fusicoccin displays toxic characteristics towards cells by increasing the rate of proton extrusion, causing acidification of the surrounding of the cell and hyperpolarization of the cell. Other experiments demonstrate that the Fusicoccin toxin also induces stimulation of H2O2 production and leakage of cytochrome c from the mitochondria which results in disturbance of the electron transport chain of the mitochondrial membrane.


References

1. Baunsgaard, L., et al. 1998. Plant J. 13: 661-671. PMID: 9681008
2. Olivari, C., et al. 1998. Plant Physiol. 116: 529-537. PMID: 9489010
3. Bunney, T.D., et al. 2003. Development. 130: 4847-4858. PMID: 12930777
4. Malerba, M., et al. 2004. Physiol Plant. 120: 386-394. PMID: 15032835

Physical State :
Solid
Derived From :
Fusicoccum amygdali
Solubility :
Soluble in 100% ethanol (10 mg/ml).
Storage :
Store at -20° C
Boiling Point :
760.19° C at 760 mmHg
Density :
1.24 g/cm3
Refractive Index :
n20D 1.56
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00070322

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Certificate of Analysis

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Fusicoccin (CAS 20108-30-9)  Product Citations

See how others have used Fusicoccin (CAS 20108-30-9). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 30824059  Yaaran, A.|Negin, B.|Moshelion, M.| et al. 2019. Plant Sci. 281: 31-40.

PMID: # 23041192  Gujas, B. et al. 2012. Curr. Biol. 22: 1962-8.

PMID: # 12196105  Borch, J. et al. 2002. Biochem. Soc. Trans. 30: 411-415.

PMID: # 31949030  Plant Physiol.

Citations 1 to 4 of 4 total

Can you resuspend it in water?

Asked by: ceci_pp
Thank you for your question. This compound is soluble in 100% ethanol (10 mg/ml).
Answered by: Tech Support Europe
Date published: 2021-04-14

What is the physical appearance? Is the product contained in a gelatin capsule?

Asked by: Jz28sail
Thank you for your question. sc-200754, Fusicoccin is a white solid and is supplied in a research vial.
Answered by: Chemical Support 5
Date published: 2017-04-04

Which is a better solvent to use, water or ethanol? What's the maximum solubility?

Asked by: chemsd02
Thank you for your question regarding sc-200754 (Fusicoccin, CAS #20108-30-9). We recommend ethanol, in which the maximum solubility is 10 mg/mL.
Answered by: Chemical Support 10
Date published: 2017-03-06
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Rated 5 out of 5 by from Malerba et al Malerba et al. (PubMed ID 15032835) found that the toxin, fusicoccin, acts on H-ATPase and induces a stimulation of H2O2 production that leads to a leakage of cytochrome C from the mitochondria. -SCBT Publication Review
Date published: 2015-06-14
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