Fumonisin B2 CAS: 116355-84-1
MF: C34H59NO14
MW: 705.83

Fumonisin B2 (CAS 116355-84-1)

Fumonisin B2 | CAS 116355-84-1 is rated 5.0 out of 5 by 1.
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Alternate Names: Fumonisin B2 is known as a fumonisin mycotoxin.
Application: Fumonisin B2 is an inhibitor of sphingosine N-acyltransferase and a a cytotoxic analog of Fumonisin B1.
CAS Number: 116355-84-1
Purity: ≥98%
Molecular Weight: 705.83
Molecular Formula: C34H59NO14
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fumonisin B2 is a structural analog of fumonisin B1(cat no.sc-201395 and sc-201395A). Fumonisin B2 is more cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase. Fumonisin B2, like other fumonisins, frequently contaminates maize and other crops. Fumonisin B2 is a fungal metabolite produced by Fusarium moniliforme. Fumonisin B2 inhibits sphingolipid biosynthesis via inhibition of sphinganine N-acyltransferase. IC50=0.1 µM in rat liver microsomes.


References

1. Shephard, G.S., et al. 1998. J Chromatogr A. 815: 31-39. PMID: 9718704

2. Bucci, T.J., et al. 1998. Toxicol Pathol. 26: 160-164. PMID: 9502399

3. Turner, P.C., et al. 1999. Mutat. Res. 443: 81-93. PMID: 10415433

4. Miller, J.D. 2001. Environ. Health Perspect. 109: 321-324. PMID: 11359702

5. Duvick, J. 2001. Environ. Health Perspect. 109: 337-342. PMID: 11359705

6. Desai, K., et al. 2002. Biochim. Biophys. Acta. 1585: 188-192. PMID: 12531553

7. Mak, A.S., et al. 1991. J. Biol. Chem. 266: 19971-19975. PMID: 1939059

8. Abbas, H.K., et al. 1993. Toxicon. 31: 345-353. PMID: 8470138

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), and methanol (10 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~864.40° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.52
IC50 :
sphinganine N-acyltransferase (ceramide synthase) : IC50 = 0.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TZ8335000
PubChem CID :
Merck Index :
14: 4289
MDL Number :
MFCD00133350
SMILES :
CCCCC(C)C(C(CC(C)CCCCCCC(CC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Abbas et al Abbas et al. (PubMed ID 8470138) found that Fumonisin B2 at 50 micrograms/ml or less exhibited toxinicity after exposure periods greater than 24 hr in all plant and animal bioassay systems examined, except 3T3 mouse fibroblasts. -SCBT Publication Review
Date published: 2015-05-21
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