FTase Inhibitor I is a potent, cell-permeable, selective, peptidomimetic inhibitor of Farnesyl Transferase (FTase). It is ~37-fold more active against Farnesyl Transferase (FTase) than against GGTase (geranylgeranyltransferase). Is also very resistant to proteolysis.
1. Cox, A D., et al., 1994. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. The Journal of biological chemistry. 269(30): 19203-6. PMID: 8034681
2. Garcia, A M., et al., 1993. Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. The Journal of biological chemistry. 268(25): 18415-8. PMID: 8360140
3. Yamaguchi, Mitsuo., et al., 2004. Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. Stroke; a journal of cerebral circulation. 35(7): 1750-5. PMID: 15143294
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