FR 122047 hydrochlorideA highly selective Cox-1 inhibitor

FR 122047 hydrochloride (CAS 130717-51-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 62ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 1-[[4,5-bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine
Application: A highly selective Cox-1 inhibitor
CAS Number: 130717-51-0
Molecular Weight: 459.99
Molecular Formula: C23H25N3O3S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

FR 122047 hydrochloride is the hydrochloride salt preparation of FR 122047 and is a Cox-1 (cyclooxygenase-1) and Cox-2 inhibitor. FR 122047 is highly selective for Cox-1 (IC50 of 0.028 μM) over Cox-2 (IC50 of 65 μM). This compound has been shown to inhibit arachidonic acid (sc-200770)-induced guinea-pig platelet aggregation in vitro. FR 122047 also displays the capacity to inhibit malondialdehyde (MDA) synthesis and cause vasodilation in vitro. Further studies suggest that FR 122047 is also capable of suppressing prostaglandin E2 (PGE2, sc-201225) and Thromboxane B2 (TXB2, sc-201452) levels which results in an anti-inflammatory effect.


1. Dohi, M., et al. 1993. Eur. J. Pharmacol. 243: 179-184. PMID: 8276067
2. Tanaka, A., et al. 1994. J. Med. Chem. 37: 1189-1199. PMID: 8164261
3. Ochi, T., et al. 2000. Eur. J. Pharmacol. 391: 49-54. PMID: 10720634
4. Ochi, T. and Goto, T. 2002. Br. J. Pharmacol. 135: 782-788. PMID: 11834626

Physical State :
Solubility :
Soluble in DMSO, water (10 mM), and methylene chloride (50 mg/ml).
Storage :
Store at -20° C
Boiling Point :
562.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.60 (Predicted)
IC50 :
Cox-1: IC50 = 28 nM (human); Cox-2: IC50 = 65 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 97ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.