FPT Inhibitor IA potent and selective farnesyltransferase inhibitor

FPT Inhibitor I

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Synonym: (E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
Application: A potent and selective farnesyltransferase inhibitor
Purity: >85%
Molecular Weight: 467.4
Molecular Formula: C19H29NO6P•3Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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FPT Inhibitor I is a highly selective and potent inhibitor of Farnesyl Transferase. FPT Inhibitor I exhibits inhibition of GGTase I and II at much higher concentrations.


References

Manne, V., et al. 1995. Drug Development Res. 34, 121. Patel, D.V., et al. 1995. J. Med. Chem. 38, 2906.

Physical State :
Solid
Solubility :
Soluble in water (≥10 mg/ml).
Storage :
Store at -80° C
Refractive Index :
n20D ~1.52 (Predicted)
IC50 :
FTase: IC50 = 83 nM; GGTase I: IC50 = 26 µM; GGTase II: IC50 = 47 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760426
MDL Number :
MFCD00270860
SMILES :
CC(=CCC/C(=C/CC/C(=C/CNC(=O)C(CP(=O)([O-])[O-])C(=O)[O-])/C)/C)C.[Na+].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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