Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The human gene FOXN4 encodes for a 476 amino acid nuclear protein designated FOXN4. FOXN4 cooperates with key retinogenic factors to mediate the multipotent differentiation of retinal progenitors and is believed to regulate neuronal subtype diversification. FOXN4 is expressed in a subset of mitotic progenitors during retinogenesis. As such, FOXN4 controls the formation of amacrine and horizontal cells by activating the expression of the retinogenic factors MATH-3, Neuro D and PROX1. During spinal neurogenesis, the p2 progenitor domain gives rise to two intermingled distinct subtypes of interneurons, termed V2a and V2b. FOXN4 is coexpressed with the bHLH factor ASH1 (Mash1) in a subset of p2 progenitors. Functionality of FOXN4 affects ASH1 expression and regulates interneuronal formation accordingly. Over-expression of FOXN4 alone in spinal neural progenitors promotes the V2a fate at the expense of the V2b fate, whereas ASH1 suppresses both the V2a and V2b fates.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with FOXN4 (H-2): sc-390456 monoclonal antibody?
Asked by: Germaine
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
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