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Fostriecin is an antibiotic originally derived from Streptomyces pulveraceus. This compound has been shown to inhibit the catalytic activity of partially purified Topo II (type II topoisomerase) in a non-competitive manner. Unlike other known inhibitors of this enzyme, fosteriecin has not been observed to cause DNA strand breaks in L1210 cells, suggesting that it does not stabilize a cleavable complex. Furthermore, in the same experiment, this agent was demonstrated to cause a block in the G2 phase of the cell cycle. Fostriecin has also displayed a strong capacity to inhibit protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A).
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See how others have used Fostriecin. Click on the entry to view the PubMed entry .
PMID: # 26196943 Lucas, SJ. et al. 2015. Neuropharmacology. 99: 232-41.
PMID: # 24462681 Amsailale, R. et al. 2014. FEBS Lett. 588: 727-32.
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PMID: # 24825897 Kang, Q. et al. 2014. The Journal of biological chemistry. 289: 17480-96.
PMID: # 23536185 Li, Y. et al. 2013. J. Biol. Chem. 288: 13215-24.
PMID: # 22142222 Zgheib, C. et al. 2012. J. Interferon Cytokine Res. 32: 87-94.
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