Fostriecin is an antibiotic originally derived from Streptomyces pulveraceus. This compound has been shown to inhibit the catalytic activity of partially purified Topo II (type II topoisomerase) in a non-competitive manner. Unlike other known inhibitors of this enzyme, fosteriecin has not been observed to cause DNA strand breaks in L1210 cells, suggesting that it does not stabilize a cleavable complex. Furthermore, in the same experiment, this agent was demonstrated to cause a block in the G2 phase of the cell cycle. Fostriecin has also displayed a strong capacity to inhibit protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A).
1. Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37: 4063-4068. PMID: 2847752
2. Roberge, M., et al. 1994. Cancer Res. 54: 6115-6121. PMID: 7954457
3. Guo, X.W., et al. 1995. EMBO J. 14: 976-985. PMID: 7889943
4. Walsh, A.H., et al. 1997. FEBS Lett. 416: 230-234. PMID: 9373158
See how others have used Fostriecin. Click on the entry to view the PubMed entry .
PMID: # 26196943 Lucas, SJ. et al. 2015. Neuropharmacology. 99: 232-41.
PMID: # 24618897 Williams, BC. et al. 2014. Elife. 3: e01695.
PMID: # 24462681 Amsailale, R. et al. 2014. FEBS Lett. 588: 727-32.
PMID: # 24825897 Kang, Q. et al. 2014. The Journal of biological chemistry. 289: 17480-96.
PMID: # 23536185 Li, Y. et al. 2013. J. Biol. Chem. 288: 13215-24.
PMID: # 22142222 Zgheib, C. et al. 2012. J. Interferon Cytokine Res. 32: 87-94.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.