Foroxymithine CAS: 100157-28-6
MF: C22H37N7O11
MW: 575.6
An angiotensin I converting enzyme inhibitor.

Foroxymithine (CAS 100157-28-6)

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Alternate Names: (3S,6S)-3-[3-[N-[N-(Nα-Acetyl-Nδ-formyl-Nδ-hydroxy-L-ornithyl)-L-seryl-N-(hydroxy)amino]propyl]-6-[3-(N-formyl-N-hydroxyamino)propyl]-2,5-piperazinedione
Application: Foroxymithine is an angiotensin I converting enzyme inhibitor
CAS Number: 100157-28-6
Purity: ≥98%
Molecular Weight: 575.6
Molecular Formula: C22H37N7O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Foroxymithine is a potent chelator of the ferrous ion and specific inhibitor of ACE (angiotensin I converting enzyme) at an IC50 of 7μg/ml. Although Foroxymithine potently inhibits ACE activity if a high enough concentration of plasma renin activity is detected by ACE the inhibitory effects will be nullified. When the compound was administered with Erbstatin Analog (sc-200511), both displayed growth inhbitiory activity against L-1210 leukemia cells in vitro.


References

1. Umezawa, H., et al. 1985. J. Antibiot. 38: 1813-1815. PMID: 3005216
2. Aoyagi, T., et al. 1985. J. Appl. Biochem. 7: 388-395. PMID: 3007425
3. Imoto, M., et al. 1987. Jpn. J. Cancer Res. 78: 329-332. PMID: 3108212

Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at -20° C
Density :
1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
angiotensin I converting enzyme: IC50 = 12.16 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VT8000000
PubChem CID :
3412
MDL Number :
MFCD00079293
SMILES :
CC(=O)NC(CCCN(C=O)O)C(=O)NC(CO)C(=O)N(CCCC1C(=O)NC(C(=O)N1)CCCN(C=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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