Fluticasone propionateA high-affinity, selective glucocorticoid receptor agonist

Fluticasone propionate (CAS 80474-14-2)

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Synonym: Flixonase
Application: A high-affinity, selective glucocorticoid receptor agonist
CAS Number: 80474-14-2
Purity: ≥98%
Molecular Weight: 500.57
Molecular Formula: C25H31F3O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fluticasone propionate is a high affinity, selective glucocorticoid receptor (GR) agonist (Kd = 0.5 nM). Fluticasone propionate potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Fluticasone propionate is a lipophilic anti-inflammatory agent derived from flumethasone (sc-211520).


References

1. Mitchison, H C., et al., 1991. A pilot study of fluticasone propionate in untreated coeliac disease. Gut. 32(3): 260-5. PMID: 1901562
2. Meltzer, E O., et al., 1990. A dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology. The Journal of allergy and clinical immunology. 86(2): 221-30. PMID: 2200821
3. Phillipps, G H., et al., 1994. Synthesis and structure-activity relationships in a series of antiinflammatory corticosteroid analogues, halomethyl androstane-17 beta-carbothioates and -17 beta-carboselenoates. Journal of medicinal chemistry. 37(22): 3717-29. PMID: 7966132

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/mL).
Storage :
Store at 4° C
Refractive Index :
n20D 1.56
Optical Activity :
α20/D 31°, c = 1 in dioxane
IC50 :
eosinophil apoptosis: EC5050 = 3.7 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
BV7980000
PubChem CID :
444036
Merck Index :
14: 4211
MDL Number :
MFCD00866007
SMILES :
CCC(=O)OC1(C(C)CC2[C@@H]3CC(F)C4=CC(=O)C=C[C@]4(C)C3(F)[C@@H](O)C[C@]12C)C(=O)SCF

Download SDS (MSDS)

Certificate of Analysis

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