FluprostenolA prostaglandin F (FP) receptor agonist

Fluprostenol (CAS 40666-16-8)

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Synonym: (±)16-(m-Trifluoromethylphenoxy)-tetranor-prostaglandin F
Application: A prostaglandin F (FP) receptor agonist
CAS Number: 40666-16-8
Purity: 98%
Molecular Weight: 458.47
Molecular Formula: C23H29F3O6
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Fluprostenol is a PGFR (prostaglandin F (FP) receptor) agonist that is more selective than PGF (sc-201227). The compound can activate phosphorylation of ERK 2 (extracellular signal-regulated kinase (ERK)), p38-Mitogen-activated protein kinase (MAPK) and JNK3 (c-Jun N-terminal kinase (JNK)) in rat aortas. Studies have shown that it can induce phospholipase C and Ca+ mobilization in human myometrial cells and can decrease intraocular pressure (IOP) by improving aqueous humor outflow through the trabecular meshwork (TM) via inhibition of endothelin (ET)-1-dependent mechanisms. Fluprostenol also suppresses the expression of adipogenic genes in 3T3-L1 cells.


1. Dukes, M., et al. 1974. Nature. 250: 330-331. PMID: 4853720
2. Carrasco, M.P., et al. 1996. J. Clin. Endocrinol. Metab. 81: 2104-2110. PMID: 8964835
3. Thieme, H., et al. 2006. Invest. Ophthalmol. Vis. Sci. 47: 938-945. PMID: 16505027
4. Rice, K.M., et al. 2010. Ann. Clin. Lab. Sci. 40: 26-31. PMID: 20124327

Formulation :
Solution in ethanol (10 mg/ml)
Physical State :
Solubility :
Soluble in ethanol (1 mg/100µL), acetone, and methanol.
Storage :
Store at -20° C
Boiling Point :
Refractive Index :
pK Values :
pKa: 4.76
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :
EC Number :

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