FluperlapineAn agonist of the serotonin 5-HT6/5-HT7 receptors

Fluperlapine (CAS 67121-76-0)

Fluperlapine | CAS 67121-76-0 is rated 5.0 out of 5 by 1.
  • y_2019, m_10, d_16, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201119, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 106ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Application: An agonist of the serotonin 5-HT6/5-HT7 receptors
CAS Number: 67121-76-0
Purity: ≥95%
Molecular Weight: 309.4
Molecular Formula: C19H20FN3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Fluperlapine is an agonist of the SR-6/SR-7 (serotonin 5-HT6/5-HT7 receptors). Agonism of the 5-HT6/5-HT7 receptors by Fluperlapine has been correlated to sedative effects. Fluperlapine is described to function similarly to Clozapine (sc-200402), and Fluperlapine is also described to be relatively resistant to chemical and biochemical oxidation as compared to Clozapine.


References

1. Matejcek, M., et al. 1984. Arzneimittelforschung. 34: 114-120. PMID: 6145426
2. Roth, B.L., et al. 1994. J. Pharmacol. Exp. Ther. 268: 1403-1410. PMID: 7908055
3. Farber, N.B., et al. 1996. Schizophr. Res. 21: 33-37. PMID: 8998274
4. Lai, W.G., et al. 2000. Drug Metab. Dispos. 28: 255-263. PMID: 10681368

Physical State :
Low-Melting Solid
Solubility :
Soluble in DMSO (10 mg/ml), and ethanol (20 mg/ml).
Storage :
Store at room temperature
Melting Point :
~18-20° C
Boiling Point :
~438.74° C at 760 mmHg (Predicted)
Density :
~1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
Ki Data :
Serotonin 2a receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2b receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2c receptor: Ki= 3.8 nM (Rattus norvegicus); Muscarinic acetylcholine receptor: Ki= 25 nM (Rattus norvegicus)
pK Values :
pKb: 7.46 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
49381
SMILES :
CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Fluperlapine  Product Citations

See how others have used Fluperlapine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 10496986  Liégeois, JF. et al. 1999. Arch. Biochem. Biophys. 370: 126-137.

PMID: # 10193665  Tatsumi, M. et al. 1999. Eur. J. Pharmacol. 368: 277-283.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 57ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Farber et al Farber et al. (PubMed ID 8998274) found that the clozapine mimic, Fluperlapine, prevented NMDA antagonist neurotoxicity in the rat brain. -SCBT Publication Review
Date published: 2015-02-18
  • y_2019, m_10, d_16, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201119, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 35ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.