Fluoxetine

Fluoxetine (CAS 54910-89-3)

Fluoxetine | CAS 54910-89-3 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_17, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_279166, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 93ms
  • REVIEWS, PRODUCT
Synonym: N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
Application: A 5-hydroxytryptamine reuptake inhibitor
CAS Number: 54910-89-3
Molecular Weight: 309.33
Molecular Formula: C17H18F3NO
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Fluoxetine is a 5-hydroxytryptamine (serotonin, 5-HT) reuptake inhibitor. This compound is a racemic mixture and both R and S enantiomers are reported to inhibit 5-HT uptake in synaptosomal preparations of rat cerebral cortex. Fluoxetine is also noted to be a highly selective, sodium dependent, ST (5-HT transporter) in studies of rat cerebrums. Additionally, Fluoxetine is also noted to increase extracellular levels of 5-HT in several areas of the rat brain as a result of reuptake inhibition. This increase in availability of 5-HT is reported to lead to a decrease in synthesis and turnover of 5-HT. It is also available as Fluoxetine HCl (sc-201125).


References

1. Wong, D.T., et al. 1995. Life Sci. 57: 411-441. PMID: 7623609
2. Beck, S.G., et al. 1997. J. Pharmacol. Exp. Ther. 281: 115-122. PMID: 9103487
3. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006

Physical State :
Solid
Solubility :
Insoluble in water.
Storage :
Store at 4° C
Melting Point :
105.27° C (Predicted)
Boiling Point :
~395.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
ST: IC50 = 0.51 nM (hamster); HERG: IC50 = 10 nM (human); Serotonin transporter: IC50 = 12.6 nM (rat); 5-HT1: IC50 = 15 nM (rat); Dopamine D2 receptor: IC50 >100 nM (rat)
Ki Data :
ST: Ki= 0.27 nM (human); Serotonin transporter: Ki= 2.7 nM (rat); Dopamine transporter: Ki= 10.8 nM (mouse); SR-2A: Ki= 55 nM (human); SR-2C: Ki= 62 nM (human)
pK Values :
pKb: 3.95
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UI4050000
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
3386
Merck Index :
12: 4222
MDL Number :
MFCD00072041
Beilstein Registry :
39914106
SMILES :
CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Fluoxetine  Product Citations

See how others have used Fluoxetine. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 28493335  Martin, V. et al. 2017. Br. J. Pharmacol. 174: 2471-2483.

PMID: # 27211904  Guo, F. et al. 2016. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26: 1087-98.

PMID: # 26336834  Svirsky, N. et al. 2016. Dev Psychobiol. 58: 71-82.

PMID: # 22334326  Wu, X. et al. 2012. Lasers in surgery and medicine. 44: 227-32.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 67ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Yu L; et al Yu L; et al. (PubMed: 26431735) determined that Fluoxetine in combination of salvianolic acid could relieve depression-like symptoms and decrease cognitive deficit induced by prolonged stress. -SCBT Publication Review
Date published: 2015-03-24
  • y_2019, m_9, d_17, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_279166, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 30ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.