Fluocinolone AcetonideA synthetic glucocorticoid VEGF inhibitor

Fluocinolone Acetonide (CAS 67-73-2)

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Application: A synthetic glucocorticoid VEGF inhibitor
CAS Number: 67-73-2
Purity: ≥98%
Molecular Weight: 452.49
Molecular Formula: C24H30F2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fluocinolone Acetonide is a synthetic glucocorticoid which acts as an inhibitor of tumor cells. Studies indicate that Fluocinolone Acetonide can inhibit promotion of tumor cells at an early stage of promotion if combined with a promoting agent. In addition, studies suggest that Fluocinolone Acetonide can regulate lipid metabolism by modulating gene expression. Alternate studies show that Fluocinolone Acetonide can inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, Fluocinolone Acetonide can inhibit TNF-α angiogenesis.


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2. Nehmé, A., et al. 2009. BMC Med Genomics. 2: 58. PMID: 19744340
3. Ayalasomayajula, S.P., et al. 2009. J Ocul Pharmacol Ther. 25: 97-103. PMID: 19284324

Appearance :
Crystalline powder
Physical State :
Solubility :
Soluble in water (partly), DMSO, alcohol ( ), chloroform, and methanol.
Storage :
Store at room temperature
Melting Point :
267-269° C (lit.)
Boiling Point :
~578.5° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +100.1°, c = 1.02 in chloroform; α20/D +103°±3°, c = 1 in methanol; α25/D +95° in chloroform
IC50 :
GR: IC50 = 3.13 nM (human); Progesterone receptor: IC50 = 26 nM (bovine)
Ki Data :
GR: Ki= 1.42 nM (human); Progesterone receptor: Ki= 3.35 nM (bovine)
pK Values :
pKa: 12.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 4150
MDL Number :
EC Number :

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Certificate of Analysis

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