FLUO 3/AMCAS: 121714-22-5
MF: C51H50Cl2N2O23
MW: 1129.85
A visible wavelength calcium probe capable of indicating changes in Ca2+ levels.

FLUO 3/AM (CAS 121714-22-5)

FLUO 3/AM | CAS 121714-22-5 is rated 5.0 out of 5 by 1.
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Synonym: Fluo-3, AM
Application: A visible wavelength calcium probe capable of indicating changes in Ca2+ levels
CAS Number: 121714-22-5
Purity: ≥88%
Molecular Weight: 1129.85
Molecular Formula: C51H50Cl2N2O23
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

FLUO 3/AM, a visible wavelength calcium probe, can be detected through fluorescent cytometry. Experiments show that this compound can be loaded into lymphocytes and fibroblasts by incubation with the pentaacetoxymethyl ester of the dye. Once inside the cell, the ester is hydrolyzed to yield genuine FLUO-3/AM capable of indicating changes in Ca2+. Other studies have reported that this FLUO 3/AM monitors Ca2+ levels without interfering with intracellular conditions. Additionally, this agent has been noted to be an effective probe for assessing the concentration and kinetics of change in mitochondrial Ca2+ under variety of conditions.


References

1. Kao, J.P., et al. 1989. J. Biol. Chem. 264: 8179-8184. PMID: 2498309
2. Saavedra-Molina, A., et al. 1990. Biochem. Biophys. Res. Commun. 167: 148-153. PMID: 2310386
3. Schumann, M.A., et al. 1993. J. Biol. Chem. 268: 2134-2140. PMID: 8380590
4. Caputo, C. and Bolaños, P. 1994. J. Physiol. 481: 119-128. PMID: 7853234

Physical State :
Solid
Solubility :
Soluble in DMSO (0.9 mg/ml), acetonitrile (2 mg/ml), and water (partly miscible).
Storage :
Store at -20° C
Boiling Point :
~1090.9° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
Fluoresence :
λex 506 nm, λem 526 nm in 0.1 M Tris pH 8.0, esterase
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5086914
MDL Number :
MFCD00083336
SMILES :
CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=C(C=CC(=C2)C3=C4C=C(C(=O)C=C4OC5=CC(=C(C=C53)Cl)OCOC(=O)C)Cl)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

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Certificate of Analysis

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FLUO 3/AM  Product Citations

See how others have used FLUO 3/AM. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 31143124  Trachtenberg, A.|Muduli, S.|Sidoryk, K.|Cybulski, M.|Danilenko, M.| et al. 2019. Front Pharmacol. 10: 507.

PMID: # 26632252  Singh, R. et al. 2015. Sci Rep. 5: 17454.

PMID: # 25972311  Lee, PY. et al. 2015. The Journal of surgical research. 197: 390-7.

PMID: # 24520246  Liu, G. et al. 2014. Exp Ther Med. 7: 565-572.

PMID: # 22262690  Zhang, WS. et al. 2012. Biology of reproduction. 86: 154, 1-7.

PMID: # 22288713  Sun, R. et al. 2012. Cell Biol. Int. 36: 475-81.

PMID: # 21593605  Chhabra, R. et al. RNA biology. 8: 648-64.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from FLUO 3/AM has been reported to be widely FLUO 3/AM has been reported to be widely used as a fluorescent indicator for measuring Ca2+, intracellularly. -SCBT Publication Review
Date published: 2015-01-03
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