Flumazenil (Ro 15-1788) CAS: 78755-81-4
MF: C15H14FN3O3
MW: 303.29
A benzodiazepine antagonist.

Flumazenil (Ro 15-1788) (CAS 78755-81-4)

Flumazenil (Ro 15-1788) | CAS 78755-81-4 is rated 5.0 out of 5 by 1.
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Alternate Names: Anexate; Romazicon; Lanexat
Application: Flumazenil (Ro 15-1788) is a benzodiazepine antagonist
CAS Number: 78755-81-4
Purity: ≥98%
Molecular Weight: 303.29
Molecular Formula: C15H14FN3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Flumazenil is an antagonist to benzodiazepine allosteric binding on the GABAA receptor. Administration of Flumazenil has been shown to reverse many of the physiological effects associated with benzodiazepines and their modification of the GABAA system.


References

1. File, S.E., et al. 1986. Psychopharmacology. 89: 113-117. PMID: 3090585
2. Mereu, G., et al. 1990. Eur. J. Pharmacol. 179: 339-345. PMID: 1973107
3. Bertz, R.J., et al. 1995. Neuropharmacology. 34: 1169-1175. PMID: 8532187

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml warm), DMSO (25 mg/ml warm), methanol, and chloroform. Partly miscible in water.
Storage :
Store at room temperature
Melting Point :
~205.38° C (Predicted)
Boiling Point :
528.0° C at 760 mmHg (Predicted)
Density :
~1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.63
IC50 :
GABA receptor alpha-1 subunit: IC50 = 0.5 nM (bovine); GABA receptor alpha-2 subunit: IC50 = 0.5 nM (bovine); GABA receptor alpha-3 subunit: IC50 = 0.5 nM (bovine); GABA receptor alpha-4 subunit: IC50 = 0.5 nM (bovine); GABA receptor beta-1 subunit: IC50 = 0.5 nM (bovine); GABA receptor gamma-2 subunit: IC50 = 0.5 nM (bovine)
Ki Data :
GABA receptor alpha-2 subunit: Ki= 0.09 nM (bovine); GABA receptor alpha-3 subunit: Ki= 0.09 nM (bovine); GABA receptor alpha-4 subunit: Ki= 0.09 nM (bovine); GABA receptor beta-1 subunit: Ki= 0.09 nM (bovine); GABA receptor gamma-2 subunit: Ki= 0.09 nM (bovine)
pK Values :
pKa: 6.2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
NI2922170
PubChem CID :
Merck Index :
14: 4135
MDL Number :
MFCD00242764
Beilstein Registry :
4763661
SMILES :
CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C

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Certificate of Analysis

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Flumazenil (Ro 15-1788) (CAS 78755-81-4)  Product Citations

See how others have used Flumazenil (Ro 15-1788) (CAS 78755-81-4). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 10784479  Le Mellédo, JM. et al. 2000. Am J Psychiatry. 157: 821-823.

PMID: # 9695999  Barbaro, G. et al. 1998. Hepatology. 28: 374-378.

PMID: # 9585710  Ströhle, A. et al. 1998. Am J Psychiatry. 155: 610-612.

PMID: # 8878099  Nave, R. et al. 1996. Neurosci. Lett. 214: 123-126.

PMID: # 8129118  Murphy, PJ. et al. 1994. Anaesthesia. 49: 105-110.

PMID: # 8267193  Ghoneim, MM. et al. 1993. Anesthesiology. 79: 1183-1192.

PMID: # 1547055  Fennelly, ME. et al. 1992. Br J Anaesth. 68: 303-305.

PMID: # 2904525  Grimm, G. et al. 1988. Lancet. 2: 1392-1394.

PMID: # 3036316  Nutt, DJ. et al. 1987. Brain Res. 413: 193-196.

PMID: # 6815546  File, SE. et al. 1982. Neuropharmacology. 21: 1033-1037.

Citations 1 to 10 of 10 total

Could you tell me at which UV range Flumazenil absorb the most and what the extinction coefficient is?

Asked by: kim0720
Unfortunately we do not have this information.
Answered by: Technical Support
Date published: 2019-09-27
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Rated 5 out of 5 by from Le Melledo et al Le Melledo et al. (PubMed ID 10784479) found flumanezil induced a significantly higher panic response in women affected with premenstrual dysphoric disorder than in control subjects.
Date published: 2015-05-11
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