Flt3 Inhibitor IV CAS: 819058-89-4
MF: C13H12N4
MW: 224.3
An ATP-competitive inhibitor of Flt3.

Flt3 Inhibitor IV (CAS 819058-89-4)

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Alternate Names: 4-(4-Aminophenyl)-1H-indazol-3-amine
Application: Flt3 Inhibitor IV is an ATP-competitive inhibitor of Flt3
CAS Number: 819058-89-4
Molecular Weight: 224.3
Molecular Formula: C13H12N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Flt3 Inhibitor IV is a 3-aminoindazole compound that acts as a strong ATP-competitive inhibitor of Flt-3/Flk-2(Flt3). Flt3 Inhibitor IV also exhibits excellent selectivity over Flk-1 (KDR/VEGFR-2) and c-Kit.


References

Dai, Y., et al. 2007. J. Med. Chem. 50, 1584.

Physical State :
Solid
Solubility :
Soluble in methanol, DMSO (100 mg/ml), DMF, and ethanol (30 mg/ml).
Storage :
Store at 4° C
Melting Point :
202.65° C (Predicted)
Boiling Point :
533.36° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.79 (Predicted)
IC50 :
Flt-3/Flk-2: IC50 = 43 nM (human); Flk-1: IC50 = 4.79 µM (human); c-Kit: IC50 = 7.36 µM (human)
pK Values :
pKb: 4.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD13176984
SMILES :
C1=CC(=C2C(=C1)NN=C2N)C3=CC=C(C=C3)N

Download SDS (MSDS)

Certificate of Analysis

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