Flt-3 Inhibitor (CAS 301305-73-7)

5.0(1)

Write a review Ask a question

See product citations (2)

Alternate Names: 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

Application: Flt-3 Inhibitor is a cell-permeable thienylcarboxamide compound that acts as an ATP-competitive

CAS Number: 301305-73-7

Purity: ≥98%

Molecular Weight: 360.43

Molecular Formula: C₁₈H₂₀N₂O₄S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

Click on image or enlarge button to enlarge

Flt-3 Inhibitor is a cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3/Flk-2 (Flt-3) inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 μM).

References

Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.

Physical State :

Solid

Solubility :

Soluble in water (<2 mg/ml), DMSO (15 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).

Storage :

Store at -20° C

Melting Point :

257.34° C (Predicted)

Boiling Point :

~454.4° C at 760 mmHg (Predicted)

Density :

~1.3 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.64 (Predicted)

IC50 :

Flt-3/Flk-2: IC₅₀ = 42 nM; MV4-11: IC₅₀ = 340 nM (human)

pK Values :

pK_a: 12.43 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

PubChem CID :

1048845

MDL Number :

MFCD00617269

SMILES :

COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents