Anti-Flg/FGFR1 Antibody (M2F12) is a mouse monoclonal IgG2a κ Flg/FGFR1 antibody, cited in 13 publications, provided at 200 µg/ml
raised against the ectodomain of Flg isoform α of human origin
Anti-Flg/FGFR1 Antibody (M2F12) is recommended for detection of Flg isoform α of mouse, rat and human origin by WB, IP, IF and IHC(P)
Anti-Flg/FGFR1 Antibody (M2F12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Flg/FGFR1 (M2F12): sc-57132.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) is the preferred secondary detection reagent for Flg/FGFR1 Antibody (M2F12) for WB and IHC(P) applications. This reagent is now offered in a bundle with Flg/FGFR1 Antibody (M2F12) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Flg Antibody (M2F12) is a high quality monoclonal Flg antibody (also designated FGFR1 antibody, or fibroblast growth factor receptor 1 antibody) suitable for the detection of the Flg protein of mouse, rat and human origin. Flg Antibody (M2F12) is available as both the non-conjugated anti-Flg antibody form, as well as multiple conjugated forms of anti-Flg antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor (FGFR-1), the Bek receptor (FGFR-2), FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Flg maps to chromosome 8p12 and is alternatively spliced to produce several isoforms. Mutations in Flg are associated with Pfeiffer syndrome (a skeletal disorder characterized by craniosynostosis with deviation and enlargement of the thumbs and great toes), brachymesophalangy with phalangeal ankylosis and a varying degree of soft tissue syndactyly. The Flg gene is also involved in chromosomal translocations with ZNF198, CEP110 and FOP, which may lead to stem cell leukemia lymphoma (SCLL).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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