Flavopiridol HydrochlorideAn inhibitor of cyclin-dependent kinases

Flavopiridol Hydrochloride (CAS 131740-09-5)

Flavopiridol Hydrochloride | CAS 131740-09-5 is rated 5.0 out of 5 by 2.
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Synonym: rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride; Alvocidib Hydrochloride
Application: An inhibitor of cyclin-dependent kinases
CAS Number: 131740-09-5
Purity: ≥99%
Molecular Weight: 438.30
Molecular Formula: C21H20ClNO5•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Flavopiridol is a synthetic flavonoid based on an extract from Dysoxylum binectariferum which has shown potential for treatment of cancer in vitro. Flavopiridol hydrochloride is a potent inhibitor of cyclin-dependent kinases (primarily Cdk1, Cdk2, and Cdk4) with an IC50 of 100 nM. The (-)-cis form induces apoptosis in particular tumor cells. At nanomolar concentrations, flavoporidol hydrochloride has been shown to reduce rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Treatment of flavopiridol decreased the activities of Cdk2 and potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells.


References

Senderowicz, A.M., et al.: J. Clin. Oncol., 16, 2986 (1998), Thomas, J.P., et al.: Cancer Chemother. Pharmacol., 50, 465 (2002), Raju, U., et al.: Cancer Res., 63, 3263 (2003), Pumfery, A., et al.: Curr. Pharm. Des., 12, 1949 (2006),

Physical State :
Solid
Solubility :
Soluble in DMSO (88 mg/ml at 25° C), methanol, water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Desiccate at -20° C
Melting Point :
196-199° C
IC50 :
CDK1: IC50 = 40 nM; CDK2: IC50 = 40 nM; CDK4: IC50 = 40 nM; CDK6: IC50 = 40 nM; CDK7: IC50 = 300 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DJ2978830
PubChem CID :
9910986
Merck Index :
14: 4094
SMILES :
CN1CCC([C@@H](C1)O)C2=C(C=C(C3=C2OC(CC3=O)C4=CC=CC=C4Cl)O)O.Cl

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Certificate of Analysis

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Flavopiridol Hydrochloride  Product Citations

See how others have used Flavopiridol Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 22699901  Kim, S. et al. 2012. J. Neurosci. 32: 8201-7.

PMID: # 21242975  Fernández, RM. et al. 2011. Oncogene. 30: 1936-1946.

Citations 1 to 2 of 2 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Flavopiridol Hydrochloride, sc-207687, is a yellow powder.
Answered by: TechService7
Date published: 2017-02-09
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Rated 5 out of 5 by from Used this chemical in cell culture studies Used this chemical in cell culture studies and works fine.
Date published: 2015-11-03
Rated 5 out of 5 by from A decrease in cyclin D1 protein expression A decrease in cyclin D1 protein expression was observed in KNRK cells post treatment with Flavopiridol Hydrochloride. -SCBT QC
Date published: 2015-04-03
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