FlavopiridolA synthetic flavonoid derivative, potent inhibitor of CDKs

Flavopiridol (CAS 146426-40-6)

Flavopiridol | CAS 146426-40-6 is rated 5.0 out of 5 by 3.
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Synonym: Alvocidib
Application: A synthetic flavonoid derivative, potent inhibitor of CDKs
CAS Number: 146426-40-6
Purity: ≥99%
Molecular Weight: 401.84
Molecular Formula: C21H20ClNO5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Flavopiridol is a synthetic flavone compound that inhibits the phosphorylation of cyclin-dependent kinases (Cdks) and suppresses expression of cyclin D1 and D3, interrupting the central role of Cdks in the regulation of the cell cycle and consequently promoting apoptosis. This action has been exploited in studies investigating the suppression of oncogenic proliferation, synovial hyperplasia, and joint destruction related to rheumatoid arthritis. Flavopiridol is an inhibitor of Cdk1, Cdk10, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8 and Cdk9.


References

1. De Azevedo, W.F., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 2735-2740. PMID: 8610110
2. Patel, V., et al. 1998. J. Clin. Invest. 102: 1674-1681. PMID: 9802881
3. Sekine, C., et al. 2008. J. Immunol. 180: 1954-1961. PMID: 18209094

Appearance :
Powder
Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in chloroform, and water (slightly soluble).
Storage :
Store at 4° C
Boiling Point :
603.56° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5287969
Merck Index :
14: 4094
MDL Number :
MFCD00894265
SMILES :
CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

Download SDS (MSDS)

Certificate of Analysis

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Flavopiridol  Product Citations

See how others have used Flavopiridol. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 26 total

PMID: # 30745144  Levasseur, MD. et al. 2019. Dev. Cell.

PMID: # 30857869  Stretton, C.|Lipina, C.|Hyde, R.|Cwiklinski, E.|Hoffmann, TM.|Taylor, PM.|Hundal, HS.| et al. 2019. Biochim Biophys Acta Mol Cell Res.

PMID: # 30257893  Monda, JK.|Cheeseman, IM.| et al. 2018. Open Biol. 8:

PMID: # 30454645  Zhang, H. et al. 2018. Cell. 175: 1244-1258.e26.

PMID: # 27457538  Liu, W.|Wu, M.|Huang, Z.|Lian, J.|Chen, J.|Wang, T.|Leung, AY.|Liao, Y.|Zhang, Z.|Liu, Q.|Yen, K.|Lin, S.|Zon, LI.|Wen, Z.|Zhang, Y.|Zhang, W.| et al. 2017. Leukemia. 31: 222-233.

PMID: # 28504701  Shao, W.|Zeitlinger, J.| et al. 2017. Nat. Genet. 49: 1045-1051.

PMID: # 28630312  2017. Proc. Natl. Acad. Sci. U.S.A. 114: E5352-E5361.

PMID: # 29036442  Lashgari, A.|Millau, JF.|Jacques, PÉ.|Gaudreau, L.| et al. 2017. Nucleic Acids Res. 45: 12715-12722.

PMID: # 28560460  Okada, Y. et al. 2017. Oncol. Rep. 38: 31-42.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

Citations 1 to 10 of 26 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-202157, is provided as a yellow solid. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-16

What is the specific solubility of this compound? I would like to use the data to make stock solutions.

Asked by: two2igm05
Thank you for your question. Flavopiridol, sc-202157, is soluble in DMSO at 15 mg/mL (37.32 mM), Ethanol at 8 mg/mL (19.9 mM), and Water at <1 mg/mL (<1 mM).
Answered by: TechService7
Date published: 2019-08-01
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Rated 5 out of 5 by from Good for control I bought this item for my Alzheimer's disease research and used as a positive control to block neorotoxicity assay, it works well for the control, and seems pretty stable in DMSO solution
Date published: 2018-02-16
Rated 5 out of 5 by from Satisfied with product Satisfied with product.
Date published: 2015-10-07
Rated 5 out of 5 by from Song Song, Y. et al. (PubMed 25528169) found Flavopiridol, a potent inhibitor of cyclin-dependent kinases, in conjunction with rev-caspases-3, resulted in a significant synergistic cell killing, significant tumor growth suppression and extended survival of mice bearing OVCAR3 cells. -SCBT Publication Review
Date published: 2015-01-25
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