FK-866 has been shown to induce apoptosis by non-competitive, and specific inhibition of nicotamide phosphoribosyltransferase (NAMPT). NAMPT is a key regulatory enzyme that mediates NAD+ biosynthesis within cells. Mechanistic studies show that this compound contains an enzymatic active site of visfatin which is optimized for nicotinamide binding and inhibition. Visfatin also contains a similar structure to insulin and mimics its actions by binding to the insulin receptors.
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See how others have used FK-866. Click on the entry to view the PubMed entry .
PMID: # 26024774 Takeuchi, M. et al. 2015. Exp. Cell Res. 335: 62-7.
PMID: # 26542945 Zucal, C. et al. 2015. BMC Cancer. 15: 855.
PMID: # 24389478 Takeuchi, M. et al. 2014. Biol. Pharm. Bull. 37: 31-6.
PMID: # 23975935 Magnifico, S. et al. 2013. FASEB J. 27: 4712-22.
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