FisetinA potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent

Fisetin (CAS 528-48-3)

Fisetin | CAS 528-48-3 is rated 5.0 out of 5 by 1.
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Synonym: 3,3',4',7-Tetrahydroxyflavone
Application: A potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent
CAS Number: 528-48-3
Purity: ≥98%
Molecular Weight: 286.24
Molecular Formula: C15H10O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fisetin is a flavone which acts as an inhibitor of Akt, Cdk6, mTOR and PI 3-kinase and an activator of ERK. It has been shown to inhibit melanoma cell growth via its mTOR binding activity.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), ethanol (3 mg/ml) at 25 °C, acetone, acetic acid, solutions of fixed alklai hydroxides, methanol, ether (very slightly), benzene (very slightly), chloroform (very slightly), hexane (very slightly), petroleum ether (very slightly), DMSO (57 mg/ml) at 25 °C, DMF, alcohol, and dilute alcohol/ NaOH showing a dark green fluorescence.
Storage :
Store at 4° C
Melting Point :
330° C (dec.)
Boiling Point :
~599.4° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.79 (Predicted)
IC50 :
Oxidative degradation of membrane lipids in microsomes: IC50 = 200 nM (rat); Glycogen synthase kinase-3 beta: IC50 = 420 nM (human); Glycogen synthase kinase-3 alpha: IC50 = 420 nM (human); CK2: IC50 = 350 nM (human); Cyclin-dependent kinase 5/CDK5 activator 1: IC50 = 570 nM (human)
Ki Data :
Butyrylcholinesterase: Ki= 90 µM (human); Acetylcholinesterase: Ki= 100.2 µM (human)
pK Values :
pKa: 6.83 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
LK9250000
PubChem CID :
5281614
Merck Index :
14: 4088
MDL Number :
MFCD00006829
EC Number :
208-434-4
Beilstein Registry :
292829
SMILES :
C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

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Certificate of Analysis

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Fisetin  Product Citations

See how others have used Fisetin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26408178  Adan, A. et al. 2016. Tumour Biol. 37: 5781-95.

PMID: # 27489195  Sak, K. et al. 2016. Food Funct. 7: 3815-24.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Prakash Prakash, D. et al. (PubMed 26411262) reported that dietary flavonoid Fisetin regulates aluminium chloride-induced neuronal apoptosis in the cortex and hippocampus of mice. -SCBT Publication Review
Date published: 2015-05-31
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