FIPI CAS: 939055-18-2
MF: C23H24FN5O2
MW: 421.5
A cell-permeable, PLD1/2 inhibitor.

FIPI (CAS 939055-18-2)

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Alternate Names: 5-Fluoro-2-Indolyl des-Chlorohalopemide
Application: FIPI is a cell-permeable, PLD1/2 inhibitor
CAS Number: 939055-18-2
Purity: ≥98%
Molecular Weight: 421.5
Molecular Formula: C23H24FN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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FIPI is a cell-permeable, PC-PLD1/2 (PLD1/2) inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. FIPI is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM.


References

1 Su, W., Yeku, O., Olepu, S., et al. 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol 75(3) 437-446 (2009). 2 Monovich, L., Mugrage, B., Quadros, E., et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett 17 2310-2311 (2007).

Physical State :
Solid
Solubility :
Soluble in 1:9 DMF:PBS(ph7.2) (~0.1 mg/ml), ethanol (~0.25 mg/ml), DMSO (~20 mg/ml), and DMF (~20 mg/ml).
Storage :
Store at -20° C
Melting Point :
295.54° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D ~1.66 (Predicted)
IC50 :
Phospholipase D1: IC50 = 1 nM (human); Phospholipase D2: IC50 = 17 nM (human)
pK Values :
pKa: 12.04 (Predicted), pKb: 8.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD18382115
SMILES :
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F

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Certificate of Analysis

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FIPI (CAS 939055-18-2)  Product Citations

See how others have used FIPI (CAS 939055-18-2). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 35269589  Cao, L.|Wang, W.|Zhang, W.|Staiger, CJ.| et al. 2022. Int J Mol Sci. 23:

PMID: # 28819302  Westphal, N. et al. 2017. Sci Rep. 7: 8622.

Citations 1 to 2 of 2 total
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