FIPI (CAS 939055-18-2)

(0)

Write a review Ask a question

See product citations (2)

Alternate Names: 5-Fluoro-2-Indolyl des-Chlorohalopemide

Application: FIPI is a cell-permeable, PLD1/2 inhibitor

CAS Number: 939055-18-2

Purity: ≥98%

Molecular Weight: 421.5

Molecular Formula: C₂₃H₂₄FN₅O₂

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

Click on image or enlarge button to enlarge

FIPI is a cell-permeable, PC-PLD1/2 (PLD1/2) inhibitor (IC₅₀ = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC₅₀ = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. FIPI is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM.

References

1 Su, W., Yeku, O., Olepu, S., et al. 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol 75(3) 437-446 (2009). 2 Monovich, L., Mugrage, B., Quadros, E., et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett 17 2310-2311 (2007).

Physical State :

Solid

Solubility :

Soluble in 1:9 DMF:PBS(ph7.2) (~0.1 mg/ml), ethanol (~0.25 mg/ml), DMSO (~20 mg/ml), and DMF (~20 mg/ml).

Storage :

Store at -20° C

Melting Point :

295.54° C (Predicted)

Density :

~1.4 g/cm³ (Predicted)

Refractive Index :

n²⁰_D ~1.66 (Predicted)

IC50 :

Phospholipase D1: IC₅₀ = 1 nM (human); Phospholipase D2: IC₅₀ = 17 nM (human)

pK Values :

pK_a: 12.04 (Predicted), pK_b: 8.53 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

16739265

MDL Number :

MFCD18382115

SMILES :

C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents