Finasteride is a synthetic 4-azasteroid antiandrogen compound. This specifically inhibits 5α-Reductase 2, an intracellular enzyme that converts the androgen testosterone into 5α dihydrotestosterone (DHT). Finasteride inhibits 5α-reductase activity in epithelium for Ki of 10nM, significantly lower than in stroma (Ki = 33nM). Finasteride is an inhibitor of 5α-Reductase 1.
1. Thigpen, A.E. and Russell, D.W. 1992. J. Biol. Chem. 267(12): 8577-8583. PMID: 1314830 2. Gao, W. et al. 2004. Endocrinology. 145(12): 5420-5428. PMID: 15308613 3. Mukai, Y. et al. 2008. Biol. Pharm. Bull. 31(9): 1646-1650. PMID: 18758053
Soluble in water (0.05 mg/ml), DMSO (75 mg/ml at 25° C), ethanol (75 mg/ml), methanol, and chloroform.
Store at 4° C
253° C (lit.)
576.6° C at 760 mmHg
~1.1 g/cm3 (Predicted)
n20D 1.52 (Predicted)
α20/D -59°, c = 1 in methanol (Predicted); α20/D +12.6°, c = 1 in methanol
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Rated 5 out of
FrauFrau, R. et al. (PubMed 26415119) used the 5 -Reductase 2 inhibitor Finasteride to demonstrate that 5 -Reductase 2 modulates the role of D1 dopamine receptors in rat sensorimotor gating. -SCBT Publication Review
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