FinasterideAn antiandrogen that inhibits 5α-Reductase 2

Finasteride (CAS 98319-26-7)

Finasteride | CAS 98319-26-7 is rated 5.0 out of 5 by 1.
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Synonym: MK 906
Application: An antiandrogen that inhibits 5α-Reductase 2
CAS Number: 98319-26-7
Molecular Weight: 372.55
Molecular Formula: C23H36N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Finasteride is a synthetic 4-azasteroid antiandrogen compound. This specifically inhibits 5α-Reductase 2, an intracellular enzyme that converts the androgen testosterone into 5α dihydrotestosterone (DHT). Finasteride inhibits 5α-reductase activity in epithelium for Ki of 10nM, significantly lower than in stroma (Ki = 33nM). Finasteride is an inhibitor of 5α-Reductase 1.


References

1. Thigpen, A.E. and Russell, D.W. 1992. J. Biol. Chem. 267(12): 8577-8583. PMID: 1314830
2. Gao, W. et al. 2004. Endocrinology. 145(12): 5420-5428. PMID: 15308613
3. Mukai, Y. et al. 2008. Biol. Pharm. Bull. 31(9): 1646-1650. PMID: 18758053

Physical State :
Solid
Solubility :
Soluble in water (0.05 mg/ml), DMSO (75 mg/ml at 25° C), ethanol (75 mg/ml), methanol, and chloroform.
Storage :
Store at 4° C
Melting Point :
253° C (lit.)
Boiling Point :
576.6° C at 760 mmHg
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
Optical Activity :
α20/D -59°, c = 1 in methanol (Predicted); α20/D +12.6°, c = 1 in methanol
IC50 :
5α-Reductase 2: IC50 = < 0.1 nM (human); 5α-Reductase 1: IC50 = 4.2 nM (human); Steroid 5-alpha-reductase: IC50 = 6.8 nM (rat); Steroid 5-alpha-reductase 1: IC50 = 10 nM (rat); type II 5α reductase: IC50 = 65 nM
Ki Data :
5α-Reductase 2: Ki= 2 nM (human); Steroid 5-alpha-reductase 1: Ki= 6.8 nM (rat); 5alpha-reductase : Ki= 10 nM (epithelium); 5alpha-reductase : Ki= 33 nM (stroma); Steroid 5-alpha-reductase: Ki= 54.7 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CL5245000
PubChem CID :
57363
Merck Index :
14: 4082
MDL Number :
MFCD00869737
Beilstein Registry :
4269024
SMILES :
CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CCC4C3(C=CC(=O)N4)C

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Certificate of Analysis

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Finasteride  Product Citations

See how others have used Finasteride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25374915  Kosaka, T. et al. 2014. Am J Clin Exp Urol. 2: 136-44.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Frau Frau, R. et al. (PubMed 26415119) used the 5 -Reductase 2 inhibitor Finasteride to demonstrate that 5 -Reductase 2 modulates the role of D1 dopamine receptors in rat sensorimotor gating. -SCBT Publication Review
Date published: 2015-07-18
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