FialuridineCAS: 69123-98-4
MF: C9H10FIN2O5
MW: 372.09
A nucleoside analog with antiviral and antihepatitis B activity.

Fialuridine (CAS 69123-98-4)

Fialuridine | CAS 69123-98-4 is rated 4.7 out of 5 by 3.
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Synonym: 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2-fluoroarauracil; FIAU; Fluoroiodoarauracil; NSC 678514
Application: A nucleoside analog with antiviral and antihepatitis B activity
CAS Number: 69123-98-4
Purity: ≥99%
Molecular Weight: 372.09
Molecular Formula: C9H10FIN2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fialuridine is a nucleoside analog with antiviral and anti-hepatitis B activity.


References

Watanabe A., et al.: J. Med. Chem., 22, 21 (1979), Colacino, J.M., et al.: Antimicrob. Agents Chemother., 24, 505 (1983), Staschke, K.A., et al.: Antiviral Res., 23, 45 (1994), Cui, L., et al.: J. Clin. Invest., 95, 555 (1995),

Physical State :
Solid
Solubility :
Soluble in methanol, water (2 mg/ml, clear, warmed), and DMF (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
209-211° C
Boiling Point :
570.75° C (Predicted)
Density :
~2.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Cowpox virus: IC50 = 240 nM
Ki Data :
Thymidine Kinase: Ki= 140 nM (human)
pK Values :
pKa: 7.94 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
YQ9512500
PubChem CID :
50313
Merck Index :
14: 4069
MDL Number :
MFCD00866922
SMILES :
C1=C(C(=O)NC(=O)N1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F)I

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Certificate of Analysis

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Fialuridine  Product Citations

See how others have used Fialuridine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27083147  Eakins, J. et al. 2016. Toxicol In Vitro. 34: 161-170.

PMID: # 23928856  Sun, N. et al. 2014. Biotechnol. Bioeng. 111: 1048-53.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Specific and Sensitive Specific and Sensitive.We use this antibody routinely in our lab, gives a very good signal by WB
Date published: 2016-10-28
Rated 4 out of 5 by from Good results Wonderful results using this antibody for IP/WB and IF with human samples.
Date published: 2016-10-28
Rated 5 out of 5 by from Xu et al Xu et al. (PubMed ID 24736310) found that Fialuridine (FIAU) induced acute liver toxicity in chimeric TK-NOG mice. -SCBT Publication Review
Date published: 2015-05-06
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