FenofibrateA hypolipidemic PPARα agonist

Fenofibrate (CAS 49562-28-9)

Fenofibrate | CAS 49562-28-9 is rated 5.0 out of 5 by 1.
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Synonym: Procetofen; Trilipix
Application: A hypolipidemic PPARα agonist
CAS Number: 49562-28-9
Purity: ≥98%
Molecular Weight: 360.83
Molecular Formula: C20H21ClO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fenofibrate is a hypolipidemic compound which acts as a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 18 μM for mouse and EC50 = 30 μM for human). Fenofibrate also binds to PPARγ with at least 10-fold less affinity, and is inactive at PPARδ at concentrations up to 100 μM.


References

Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981) Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999) Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006) In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006) PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008)

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in acetone, ether, DMSO (15 mg/ml), DMF (30 mg/ml), ethanol (1 mg/ml), methanol (slightly soluble), benzene, chloroform, DMF:PBS (1:3 pH 7.2) (0.25 mg/ml), ethyl acetate, acetonitrile, and hexane. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
79-83° C
Boiling Point :
469.77° C at 760 mmHg (Predicted)
Density :
1.18 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Dopamine transporter: IC50 = 8.63 µM (human); Acetylcholinesterase: IC50 = 15.55 µM (human); LoVo: IC50 = 13.2 µM (human); Serotonin 2a receptor: IC50 = 2.12 µM (human); ADORA3 protein: IC50 = 5.7 µM (human); Peroxisome proliferator-activated receptor alpha: IC50 = 1 µM (human); PPARα: EC5050 = 18 µM (murine); PPARα: EC5050 = 30 µM (human)
Ki Data :
ADORA3 protein: Ki= 3.22 µM (human); Serotonin 2c receptor: Ki= 1.24 µM (human); Fatty acid-binding protein, liver: Ki= 0.41 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UA2453400
PubChem CID :
3339
Merck Index :
14: 3978
MDL Number :
MFCD00133314
EC Number :
256-376-3
SMILES :
CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1

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Fenofibrate  Product Citations

See how others have used Fenofibrate. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26872613  Rotondi, S. et al. 2016. Mol. Cell. Endocrinol.

PMID: # 26617775  Zuo, N. et al. 2015. Int J Clin Exp Pathol. 8: 10653-61.

PMID: # 25881202  Ann, SJ. et al. 2015. Atherosclerosis. 240: 389-97.

PMID: # 23747828  Petrescu, AD. et al. 2013. Biochim. Biophys. Acta. 1831: 1412-25.

Citations 1 to 4 of 4 total

Dear, could you please send me a price quote for 10kg of fenofibrate? Could you also send me some information about the API (morphology, PSD) as this material will be used in a PhD project? Best regards, Maxim.

Asked by: Maxim Pauwels
Thank you for your question. Please contact our Special Orders Department to inquire about the possibility of a bulk order for this biochemical. Email us at specialorders@scbt.com.
Answered by: Tech Service
Date published: 2018-08-03
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Rated 5 out of 5 by from Wu Wu, Y. et al. (PubMed 26387199) used Fenofibrate, a PPAR agonist, to demonstrate that PPAR- can negatively regulate cardiomyocyte hypertrophy. -SCBT Publication Review
Date published: 2015-03-14
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