Fenofibrate is a hypolipidemic compound which acts as a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 18 μM for mouse and EC50 = 30 μM for human). Fenofibrate also binds to PPARγ with at least 10-fold less affinity, and is inactive at PPARδ at concentrations up to 100 μM.
Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981) Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999) Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006) In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006) PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008)
See how others have used Fenofibrate. Click on the entry to view the PubMed entry .
PMID: # 26872613 Rotondi, S. et al. 2016. Mol. Cell. Endocrinol.
PMID: # 26617775 Zuo, N. et al. 2015. Int J Clin Exp Pathol. 8: 10653-61.
PMID: # 25881202 Ann, SJ. et al. 2015. Atherosclerosis. 240: 389-97.
PMID: # 23747828 Petrescu, AD. et al. 2013. Biochim. Biophys. Acta. 1831: 1412-25.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.