Felodipine is a 1,4-dihydropyridine small molecule antagonist and calcium channel protein inhibitor. Antagonism of the vascular L-type (long-lasting) calcium channel decreases intracellular calcium concentration, softening the tone of vascular tissue and decreasing the peripheral resistance upon the blood stream, effectively decreasing systemic arterial blood pressure without affecting myocardial contractility. Felodipine is described to inhibit cytokine-induced NO and superoxide production as well as cytokine-induced NO synthase (NOS) mRNA induction, and is suggested to act as a scavenger of superoxide and not an inhibitor of inducible NOS induction. This indicates that Felodipine further protects the vasculature against endogenous free radical generation during inflammatory responses.
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Soluble in DMSO (>25 mg/ml), ethanol (20 mg/ml), methanol, chloroform, and acetone. Insoluble in water.
Store at room temperature
471.52° C at 760 mmHg
Calcium channel: IC50 = 1.45 nM (Cavia porcellus); Sodium channel protein type III alpha subunit: IC50 = 37000 nM (human); Sodium channel protein type I alpha subunit: IC50 = 37000 nM (human); Danio rerio: IC50 = 9210 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
Hishikawa et alHishikawa et al. (PubMed ID 9856965) found that Felodipine inhibited the production of free radicals by cytokines and glucose, exerting a vascular protective effect in human smooth muscle cells after induced inflammation. -SCBT Publication Review
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