Feglymycin is an amphoteric, 13-member, linear peptide featuring 3,5-dihydroxyphenylalanine and a terminal dicarboxylate amino acid, isolated from a Streptomyces in 1999. Feglymycin is a potent antiviral agent with antibacterial activity, including against MRSA. Feglymycin specifically inhibits the enzymes MurA and MurC and inhibits cell-to-cell transfer between HIV-infected T cells, uninfected CD4+ T cells, and the DC-SIGN- mediated viral transfer to CD4+ T cells.
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