FCCPAn oxidative phosphorylation uncoupler in mitochondria

FCCP (CAS 370-86-5)

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Synonym: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Application: An oxidative phosphorylation uncoupler in mitochondria
CAS Number: 370-86-5
Purity: ≥95%
Molecular Weight: 254.17
Molecular Formula: C10H5F3N4O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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FCCP is an oxidative phosphorylation uncoupler in mitochondria.


References

1. Heytler, P.G. and Pritchard, W.W. 1962. Biochem. Biophys. Res. Comm. 7: 272-275.
2. Connop, B.P., et al. 1999. J. Neurochem. 72: 1457-1465.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), methanol, ethanol, and acetone (20 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
174-175° C (lit.)(dec.)
Boiling Point :
293.27° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
1, 10-phenanthroline-induced HIF1 activation: IC50 = 310 nM (human T47D cells); hypoxia-induced HIF1 activation: IC50 = 510 nM (human T47D cells)
pK Values :
pKa: 5.91 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
FG5775000
PubChem CID :
3330
MDL Number :
MFCD00009699
EC Number :
206-730-8
Beilstein Registry :
664446
SMILES :
C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F

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FCCP  Product Citations

See how others have used FCCP. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 31234244  Sugiyama, Y.|Shudo, T.|Hosokawa, S.|Watanabe, A.|Nakano, M.|Kakizuka, A.| et al. 2019. Genes Cells. 24: 569-584.

PMID: # 31447347  Mondragón, L.|Mhaidly, R.|De Donatis, GM.|Tosolini, M.|Dao, P.|Martin, AR.|Pons, C.|Chiche, J.|Jacquin, M.|Imbert, V.|Proïcs, E.|Boyer, L.|Doye, A.|Luciano, F.|Neels, JG.|Coutant, F.|Fabien, N.|Sormani, L.|Rubio-Patiño, C.|Bossowski, JP.|Muller, F.|Marchetti, S.|Villa, E.|Peyron, JF.|Gaulard, P.|Lemonnier, F.|Asnafi, V.|Genestier, L.|Benhida, R.|Fournié, JJ.|Passeron, T.|Ricci, JE.|Verhoeyen, E.| et al. 2019. Cancer Cell.

PMID: # 30846317  Zhu, XG.|Nicholson Puthenveedu, S.|Shen, Y.|La, K.|Ozlu, C.|Wang, T.|Klompstra, D.|Gultekin, Y.|Chi, J.|Fidelin, J.|Peng, T.|Molina, H.|Hang, HC.|Min, W.|Birsoy, K.| et al. 2019. Mol. Cell.

PMID: # 30250075  Shen, Q.|Li, J.|Mai, J.|Zhang, Z.|Fisher, A.|Wu, X.|Li, Z.|Ramirez, MR.|Chen, S.|Shen, H.| et al. 2018. Cell Death Dis. 9: 986.

PMID: # 28597245  Schaefer, S.|Guerra, B.| et al. 2017. Mol. Cell. Biochem. 436: 137-150.

PMID: # 27923773  Burr, SP. et al. 2016. Cell metabolism. 24: 740-752.

PMID: # 26707617  von Ballmoos, C. et al. 2016. Biochimica et biophysica acta. 1857: 321-31.

PMID: # 27545456  Eskiocak, U.|Ramesh, V.|Gill, JG.|Zhao, Z.|Yuan, SW.|Wang, M.|Vandergriff, T.|Shackleton, M.|Quintana, E.|Johnson, TM.|DeBerardinis, RJ.|Morrison, SJ.| et al. 2016. Nat Commun. 7: 12336.

PMID: # 26604148  Casadei, N. et al. 2016. Hum. Mol. Genet. 25: 459-71.

PMID: # 26319055  Rodrigues, ET. et al. 2015. Environ. Pollut. 206: 619-26.

Citations 1 to 10 of 11 total
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