Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Fc ε RIβ Antibody (5-RE9) is a high quality monoclonal Fc epsilon RI beta antibody (also designated Fc ε RIβ antibody) suitable for the detection of the Fc epsilon RI beta protein of human origin. Fc ε RIβ Antibody (5-RE9) is available as the non-conjugated anti-Fc epsilon RI beta antibody. IgE Fc Receptor I binds to the Fc region of immunoglobulins epsilon chain with high affinity, and is responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamines, responsible for the manifestations of allergy. IgE Fc Receptor I also induces the secretion of important lymphokines, effectors of the hypersensitivity response. It is a tetramer of a heavily glycosylated alpha chain, a beta chain, and two disulfide linked gamma chains. Structurally, the beta chain contains four transmembrane regions with long cytoplasmic domains potentially involved in intracellular signaling. The cytoplasmic domains of the beta and gamma subunits each contain a conserved consesus sequence, ITAM, (immunoreceptor tyrosine activation motif). Phosphorylation of a pair of conserved tyrosine residues within this motif is required for signal transduction in mast cells and other hemopoietic cell types. A variant identified at Glu-237 of the beta subunit has been implicated as a risk factor for atopic dermatitis and asthma.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn