F16 CAS: 36098-33-6
MF: C16H15IN2
MW: 362.2
A cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines.

F16 (CAS 36098-33-6)

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Alternate Names: 4-[(E)-2-(Indol-3-yl)ethenyl]-N-methylpyridinium iodide
Application: F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines
CAS Number: 36098-33-6
Molecular Weight: 362.2
Molecular Formula: C16H15IN2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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F16 is a cell-permeable, fluorogenic, delocalized lipophilic cationic compound that acts as a mitochondrial toxin and possesses the dual ability to induce apoptosis as well as necrosis in tumor cells. F16 preferentially accumulates in mitochondria, inhibits oxidative phosphorylation and causes mitochondrial transmembrane depolarization. The incorporation and localization of F16 can be easily monitored by its fluorescence property.


References

Fantin, V.R., and Leder, P. 2004. Cancer Res. 64, 329. Fantin, V.R., et al. 2002. Cancer Cell 2, 29.

Physical State :
Solid
Solubility :
DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C[N+]1=CC=C(C=C1)/C=C/C2=CNC3=CC=CC=C32.[I-]

Download SDS (MSDS)

Certificate of Analysis

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