F16 is a cell-permeable, fluorogenic, delocalized lipophilic cationic compound that acts as a mitochondrial toxin and possesses the dual ability to induce apoptosis as well as necrosis in tumor cells. F16 preferentially accumulates in mitochondria, inhibits oxidative phosphorylation and causes mitochondrial transmembrane depolarization. The incorporation and localization of F16 can be easily monitored by its fluorescence property.
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