Exotoxin A, Pseudomonas aeruginosaProtein synthesis inhibitor via Bak expression level regulation

Exotoxin A, Pseudomonas aeruginosa (CAS 91262-95-2)

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Application: Protein synthesis inhibitor via Bak expression level regulation
CAS Number: 91262-95-2
Molecular Weight: 66000
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Exotoxin A, Pseudomonas aeruginosa, a bacterial toxin originally derived from Pseudomonas aeruginosa, has been shown to arrest protein synthesis and cause apoptosis. Mechanistic studies suggest that this compound causes apoptosis via Bak regulation. Additional experiments report that exposure of cells to Exotoxin A results in an increase in TNF-α, IL-2, IL-6, and IL-10 levels which eventually lead to apoptosis.


References

1. Wolf, P., et al. 2009. Int. J. Med. Microbiol. 299: 161-176. PMID: 18948059
2. Chiu, C.C., et al. 2009. J. Vet. Med. Sci. 7: 1-8. PMID: 19194069
3. Du, X., et al. 2010. Mol. Cell. Biol. 30: 3444-3452. PMID: 20457813

Physical State :
Solid
Solubility :
Soluble in water, 10 mM Tris-HCl, pH 8.0 (0.5 mg/ml), and neutral aqueous buffers (resulting in clear to slightly hazy, colorless solution).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LF2991000
MDL Number :
MFCD00132134

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