Exo1An inhibitor of protein traffic emanating from the ER which acts by inducing the fast collapse of the Golgi

Exo1 (CAS 461681-88-9)

Exo1 | CAS 461681-88-9 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_19, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3-b1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200752, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 89ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: EXOCYTIC INHIBITOR 1;2-[(4-Fluorobenzoyl)amino]benzoic acid methyl ester
Application: An inhibitor of protein traffic emanating from the ER which acts by inducing the fast collapse of the Golgi
CAS Number: 461681-88-9
Purity: ≥98%
Molecular Weight: 273.26
Molecular Formula: C15H12FNO3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Exo1 is a compound which disrupts the functions of the Golgi apparatus by causing a fast collapse of the organelle. It is known that the Golgi functions to package proteins in order to prepare them from secretion. Exo1 can disrupt this function by releasing ARF1 (ADP-ribosylation factor 1) from membranes of the Golgi. In addition, Exo1 can be an essential tool in differentiating between Bars50 and ARF1 fatty acid exchange activity as a result of the lack of interaction between Exo1 and guanine nucleotide exchange factors. Furthermore, Exo1 reduces the traffic of proteins emanating from the endoplasmic reticulum.


References

1. Feng, Y., et al. 2003. Proc. Natl. Acad. Sci. U.S.A. 100: 6469-6474. PMID: 12738886
2. Bau, D.T., et al. 2009. Chin J Physiol. 52: 411-418. PMID: 20337148
3. Bolderson, E., et al. 2010. Nucleic Acids Res. 38: 1821-1831. PMID: 20019063

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), DMF (20 mg/ml), ethanol (5 mg/ml), and methanol.
Storage :
Store at room temperature
Melting Point :
132-134° C
Refractive Index :
n20D 1.61
IC50 :
vesicular traffic from ER to Golgi: IC50 = 20 mM (BSC1 cells)
pK Values :
pKa: 12.78
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
310557
MDL Number :
MFCD00028104
SMILES :
COC(=O)C1=CC=CC=C1NC(=O)C2=CC=C(C=C2)F

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Exo1  Product Citations

See how others have used Exo1. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 26275776  Iannascoli, C. et al. 2015. Nucleic Acids Res. 43: 9788-803.

PMID: # 23994874  Chandramouly, G. et al. 2013. Nat Commun. 4: 2404.

PMID: # 24185178  Reiling, JH. et al. 2013. Nature cell biology. 15: 1473-85.

PMID: # 19067489  Beller, M. et al. 2008. PLoS Biol. 6: -.

PMID: # 12738886  Feng, Y. et al. 2003. Proc. Natl. Acad. Sci. U.S.A. 100: 6469-6474.

Citations 1 to 5 of 5 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 60ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Beller et al Beller et al. (PubMed ID 19067489) used Exo1 to inhibit Coat Protein Complex 1 function. -SCBT Publication Review
Date published: 2015-05-27
  • y_2019, m_11, d_19, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3-b1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200752, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.