ETYA (5,8,11,14-eicosatetraynoic acid) has been shown to be a competitive inhibitor of arachidonic acid (sc-200770) metabolism. Experiments have demonstrated ETYA as an inhibitor of the secretory response of isolated rat pancreatic islets to arginine and glucose. ETYA has also been found to stimulate luteinizing hormone in vitro and inhibit Cox-1 (cyclooxygenase-1), PLA2, 5-LO, 12-LO and 15-LO (lipoxygenase). Additionally, ETYA demonstrates the capacity to selectively activate TRPA1, which may play a role in mediation of pain. ETYA is an inhibitor of CYP and an activator of PPARα and PPARγ.
1. Conn, P.M., et al. 1980. Prostaglandins. 19: 873-879. PMID: 6770421 2. Chi, E.Y., et al. 1982. Lab. Invest. 47: 579-585. PMID: 6815379 3. Falck, J.R., et al. 1983. Biochem. Biophys. Res. Commun. 114: 743-749. PMID: 6411091 4. Taylor, A.S., et al. 1985. Prostaglandins. 29: 449-458. PMID: 3923563 5. Maher, M., et al. 2008. Mol. Pharmacol. 73: 1225-1234. PMID: 18171730
Soluble in DMSO, ethanol (~10 mg/ml), DMSO&DMF (~100 mg/ml), methanol, acetone, and acetonitrile.
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Taylor et alTaylor et al. (PubMed ID 3923563) found that ETYA, a cyclooxygenase and lipoxygenase inhibitor, blocked the incorporation of 14C-arachidonic acid into lipid cells and inhibited acyl CoA synthetase in lymphocytes. -SCBT Publication Review
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