ETYAA Cox, LO, and PLA2 inhibitor

ETYA (CAS 1191-85-1)

ETYA | CAS 1191-85-1 is rated 5.0 out of 5 by 1.
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Synonym: 5,8,11,14-Eicosatetraynoic acid
Application: A Cox, LO, and PLA2 inhibitor
CAS Number: 1191-85-1
Purity: ≥98%
Molecular Weight: 296.40
Molecular Formula: C20H24O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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ETYA (5,8,11,14-eicosatetraynoic acid) has been shown to be a competitive inhibitor of arachidonic acid (sc-200770) metabolism. Experiments have demonstrated ETYA as an inhibitor of the secretory response of isolated rat pancreatic islets to arginine and glucose. ETYA has also been found to stimulate luteinizing hormone in vitro and inhibit Cox-1 (cyclooxygenase-1), PLA2, 5-LO, 12-LO and 15-LO (lipoxygenase). Additionally, ETYA demonstrates the capacity to selectively activate TRPA1, which may play a role in mediation of pain. ETYA is an inhibitor of CYP and an activator of PPARα and PPARγ.


References

1. Conn, P.M., et al. 1980. Prostaglandins. 19: 873-879. PMID: 6770421
2. Chi, E.Y., et al. 1982. Lab. Invest. 47: 579-585. PMID: 6815379
3. Falck, J.R., et al. 1983. Biochem. Biophys. Res. Commun. 114: 743-749. PMID: 6411091
4. Taylor, A.S., et al. 1985. Prostaglandins. 29: 449-458. PMID: 3923563
5. Maher, M., et al. 2008. Mol. Pharmacol. 73: 1225-1234. PMID: 18171730

Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol (~10 mg/ml), DMSO&DMF (~100 mg/ml), methanol, acetone, and acetonitrile.
Storage :
Store at -20° C
Melting Point :
79-81° C
Boiling Point :
~490.3° C at 760 mmHg (Predicted)
Density :
1.03 g/cm3
Refractive Index :
n20D 1.53
IC50 :
Induced myeloid leukemia cell differentiation protein Mcl-1: IC50 = 441.49 nM (human); Candida albicans: IC50 = 1700 nM; Trichophyton rubrum: IC50 = 2900 nM; Candida albicans: IC50 = 8100 nM (Rattus norvegicus); Candida tropicalis: IC50 = 27700 nM (Candida tropicalis)
pK Values :
pKa: 4.61
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1780
MDL Number :
MFCD00036967
Beilstein Registry :
1798411
SMILES :
CCCCCC#CCC#CCC#CCC#CCCCC(=O)O

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Certificate of Analysis

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ETYA  Product Citations

See how others have used ETYA. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23387427  2013. ACS Chem. Biol. 8: 840-8.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Taylor et al Taylor et al. (PubMed ID 3923563) found that ETYA, a cyclooxygenase and lipoxygenase inhibitor, blocked the incorporation of 14C-arachidonic acid into lipid cells and inhibited acyl CoA synthetase in lymphocytes. -SCBT Publication Review
Date published: 2015-03-03
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